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MGP002887

UniProt Annotations

Entry Information
Gene Namesolute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
Protein EntryNRAM1_HUMAN
UniProt IDP49279
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P49279-1; Sequence=Displayed; Name=2; IsoId=P49279-2; Sequence=VSP_047875, VSP_047876; Note=No experimental confirmation available.;
FunctionDivalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
InductionIn response to lymphokine or bacterial products.
PolymorphismGenetic variation in SLC11A1 is associated with susceptibility to infection with Mycobacterium ulcerans [MIM:610446].
PolymorphismGenetic variations in SLC11A1 determine Mycobacterium tuberculosis susceptibility [MIM:607948].
SimilarityBelongs to the NRAMP family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityMacrophages; peripheral blood leukocytes, lung, spleen and liver.
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