MGP Database

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MGP002900

Record overview

MGPD IDMGP002900
Gene ID6571
SpeciesHomo sapiens (Human)
Gene Namesolute carrier family 18 (vesicular monoamine transporter), member 2
Gene Symbol SLC18A2
SynonymsSVAT; SVMT; VAT2; VMAT2;
Alternate namessynaptic vesicular amine transporter; monoamine neurotransmitter transporter; monoamine transporter; solute carrier family 18 (vesicular monoamine), member 2; solute carrier family 18 member 2; vesicle monoamine transporter type 2; vesicle monoamine/H+ antiporter; vesicular amine transporter 2;
Chromosome10
Map Location10q25
SummaryThe vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011]
OrthologsView orthologs and multiple alignments for SLC18A2

Proteins

synaptic vesicular amine transporter
Refseq ID:NP_003045
Protein GI:42476325
UniProt ID:Q05940
mRNA ID:NM_003054
Length:514
RefSeq Status:
MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEIQTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQ
TATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSSSYAFLLIARSLQGIGSSCSS
VAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGS
ICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDS
SMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNI
QSYPIGEDEESESD
 
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