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MGP002900

UniProt Annotations

Entry Information
Gene Namesolute carrier family 18 (vesicular monoamine transporter), member 2
Protein EntryVMAT2_HUMAN
UniProt IDQ05940
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q05940-1; Sequence=Displayed; Name=2; IsoId=Q05940-2; Sequence=VSP_057151, VSP_057152; Note=No experimental confirmation available.;
FunctionInvolved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.
Sequence CautionSequence=BAB19009.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the major facilitator superfamily. Vesicular transporter family. {ECO:0000305}.
Subcellular LocationCytoplasmic vesicle membrane; Multi-pass membrane protein.
SubunitInteracts with SLC6A3. {ECO:0000250}.
Web ResourceName=Wikipedia; Note=Vesicular monoamine transporter entry; URL="http://en.wikipedia.org/wiki/Vesicular_monoamine_transporter";
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