MGP Database

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MGP002909

UniProt Annotations

Entry Information
Gene Namesolute carrier family 22 (organic cation transporter), member 3
Protein EntryS22A3_HUMAN
UniProt IDO75751
SpeciesHuman
Comments
Comment typeDescription
FunctionMediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. {ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924}.
InteractionP00519:ABL1; NbExp=2; IntAct=EBI-1752674, EBI-375543;
SimilarityBelongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
Tissue SpecificityExpressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen. {ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924, ECO:0000269|PubMed:9933568}.
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