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MGP002927

Record overview

MGPD IDMGP002927
Gene ID6610
SpeciesHomo sapiens (Human)
Gene Namesphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
Gene Symbol SMPD2
SynonymsISC1; NSMASE; NSMASE1;
Alternate namessphingomyelin phosphodiesterase 2; N-SMase; lyso-PAF-PLC; lyso-platelet-activating factor-phospholipase C; neutral sphingomyelinase;
Chromosome6
Map Location6q21
EC Number3.1.4.12
SummaryThis gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]
OrthologsView orthologs and multiple alignments for SMPD2

Proteins

sphingomyelin phosphodiesterase 2
Refseq ID:NP_003071
Protein GI:92859618
UniProt ID:O60906
mRNA ID:NM_003080
Length:423
RefSeq Status:
MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTL
NGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDA
YLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERS
PLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQ
DLGPEPQPALLLGQQEGDRTKEQ
 
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