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MGP002929

UniProt Annotations

Entry Information
Gene Namesmall ubiquitin-like modifier 3
Protein EntrySUMO3_HUMAN
UniProt IDP55854
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P55854-1; Sequence=Displayed; Name=2; IsoId=P55854-2; Sequence=VSP_054693; Note=No experimental confirmation available.;
FunctionUbiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678}.
InteractionO43290:SART1; NbExp=2; IntAct=EBI-474067, EBI-607761; P23497:SP100; NbExp=2; IntAct=EBI-474067, EBI-751145; Q5W0Q7:USPL1; NbExp=13; IntAct=EBI-474067, EBI-2513899;
PtmCleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.
PtmPolymeric chains can be formed through Lys-11 cross-linking.
SimilarityBelongs to the ubiquitin family. SUMO subfamily. {ECO:0000305}.
SimilarityContains 1 ubiquitin-like domain. {ECO:0000255|PROSITE-ProRule:PRU00214}.
Subcellular LocationCytoplasm. Nucleus. Nucleus, PML body {ECO:0000250}.
SubunitCovalently attached to a number of proteins. Interacts with ARNTL/BMAL1 (By similarity). Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with SAE2 and UBE2I. {ECO:0000250, ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:12924945, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:18538659}.
Tissue SpecificityExpressed predominantly in liver. {ECO:0000269|PubMed:15487983}.
Web ResourceName=Wikipedia; Note=SUMO protein entry; URL="http://en.wikipedia.org/wiki/SUMO_protein";
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