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MGP002931

Record overview

MGPD IDMGP002931
Gene ID6616
SpeciesHomo sapiens (Human)
Gene Namesynaptosomal-associated protein, 25kDa
Gene Symbol SNAP25
SynonymsRIC4; SEC9; SNAP; RIC-4; SNAP-25; bA416N4.2; dJ1068F16.2;
Alternate namessynaptosomal-associated protein 25; SUP; resistance to inhibitors of cholinesterase 4 homolog; super protein; synaptosomal-associated protein, 25kD;
Chromosome20
Map Location20p12-p11.2
SummarySynaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for SNAP25

Proteins

synaptosomal-associated protein 25 isoform SNAP25A
Refseq ID:NP_003072
Protein GI:18765733
UniProt ID:P60880
mRNA ID:NM_003081
Length:206
RefSeq Status:
MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLDRVEEGMNHINQDMKEAEKNLKDLGKCCGLFICPCNKLKSSDA
YKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRAT
KMLGSG
 
synaptosomal-associated protein 25 isoform SNAP25B
Refseq ID:NP_570824
Protein GI:18765735
UniProt ID:P60880
mRNA ID:NM_130811
Length:206
RefSeq Status:
MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNLTDLGKFCGLCVCPCNKLKSSDA
YKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRAT
KMLGSG
 
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