MGP Database

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MGP002931

UniProt Annotations

Entry Information
Gene Namesynaptosomal-associated protein, 25kDa
Protein EntrySNP25_HUMAN
UniProt IDP60880
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Comment=Isoforms differ by the usage of two alternative homologous exons (5a and 5b) which code for positions 56 to 94 and differ only in 9 positions out of 39.; Name=1; Synonyms=SNAP-25b; IsoId=P60880-1, P13795-1; Sequence=Displayed; Name=2; Synonyms=SNAP-25a; IsoId=P60880-2, P13795-2; Sequence=VSP_006186;
Functiont-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.
InteractionQ8IUH5:ZDHHC17; NbExp=3; IntAct=EBI-524785, EBI-524753;
MiscellaneousWhen cloned and expressed in Eschericia coli, where protein palmitoylation does not occur, Cys-85, Cys-88, Cys-90 and Cys-92 in the protein sequence readily form an iron-sulfur cluster instead.
PtmPalmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association (By similarity). {ECO:0000250}.
SimilarityBelongs to the SNAP-25 family. {ECO:0000305}.
SimilarityContains 2 t-SNARE coiled-coil homology domains. {ECO:0000255|PROSITE-ProRule:PRU00202}.
Subcellular LocationCytoplasm, perinuclear region {ECO:0000250}. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Note=Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region (By similarity). {ECO:0000250}.
SubunitPart of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds CPLX1. Interacts with CENPF, TRIM9, RIMS1, SNAPIN, OTOF and HGS. Binds STXBP6. Found in a ternary complex with STX1A and VAMP8. Found in a complex containing SYT1, SV2B and syntaxin-1 (By similarity). Associates with the BLOC-1 complex. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with EQTN (By similarity). {ECO:0000250}.
Tissue SpecificityNeurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum.
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