MGP Database

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MGP002946

UniProt Annotations

Entry Information
Gene Namesyntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
Protein EntrySNTB1_HUMAN
UniProt IDQ13884
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13884-1; Sequence=Displayed; Name=2; IsoId=Q13884-2; Sequence=VSP_006354, VSP_006355; Note=No experimental confirmation available.;
DomainThe PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity). {ECO:0000250}.
DomainThe PH 1 domain mediates the oligomerization in a calcium dependent manner. {ECO:0000250}.
DomainThe SU domain binds calmodulin in a calcium-dependent manner. {ECO:0000250}.
FunctionAdapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
InteractionO95477:ABCA1; NbExp=3; IntAct=EBI-295843, EBI-784112; P11532:DMD; NbExp=3; IntAct=EBI-295843, EBI-295827;
PtmPhosphorylated by CaM-kinase II. {ECO:0000250}.
SimilarityBelongs to the syntrophin family. {ECO:0000305}.
SimilarityContains 1 PDZ (DHR) domain. {ECO:0000255|PROSITE- ProRule:PRU00143}.
SimilarityContains 1 SU (syntrophin unique) domain. {ECO:0000305}.
SimilarityContains 2 PH domains. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular LocationCell membrane, sarcolemma {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions. {ECO:0000250}.
SubunitMonomer and homodimer (Probable). Interacts with the other members of the syntrophin family SNTA1 and SNTB2; with the sodium channel proteins SCN4A and SCN5A (By similarity). Interacts with the viral HTLV-1 TAX protein and with dystrophin protein DMD and related proteins DTNA and UTRN. {ECO:0000250, ECO:0000269|PubMed:7844150, ECO:0000269|PubMed:9482110, ECO:0000305}.
Tissue SpecificityUbiquitous. {ECO:0000269|PubMed:8183929}.
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