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MGP002949

UniProt Annotations

Entry Information
Gene Namesterol O-acyltransferase 1
Protein EntrySOAT1_HUMAN
UniProt IDP35610
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P35610-1; Sequence=Displayed; Name=2; IsoId=P35610-2; Sequence=VSP_045331; Name=3; IsoId=P35610-3; Sequence=VSP_045330;
Catalytic ActivityAcyl-CoA + cholesterol = CoA + cholesterol ester.
FunctionCatalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.
InductionHighly activated by the presence of cholesterol.
InteractionQ9Y5Z9:UBIAD1; NbExp=3; IntAct=EBI-6621997, EBI-2819725;
SimilarityBelongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:16154994}; Multi-pass membrane protein {ECO:0000269|PubMed:16154994}.
SubunitMay form homo- or heterodimers. Interacts with UBIAD1. {ECO:0000269|PubMed:23169578}.
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