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MGP002950

Record overview

MGPD IDMGP002950
Gene ID6647
SpeciesHomo sapiens (Human)
Gene Namesuperoxide dismutase 1, soluble
Gene Symbol SOD1
SynonymsALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer;
Alternate namessuperoxide dismutase [Cu-Zn]; Cu/Zn superoxide dismutase; SOD, soluble; epididymis secretory protein Li 44; indophenoloxidase A; superoxide dismutase, cystolic;
Chromosome21
Map Location21q22.11
EC Number1.15.1.1
SummaryThe protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for SOD1

Proteins

superoxide dismutase [Cu-Zn]
Refseq ID:NP_000445
Protein GI:4507149
UniProt ID:P00441
mRNA ID:NM_000454
Length:154
RefSeq Status:
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSI
EDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
 
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