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MGP002952

Record overview

MGPD IDMGP002952
Gene ID6649
SpeciesHomo sapiens (Human)
Gene Namesuperoxide dismutase 3, extracellular
Gene Symbol SOD3
SynonymsEC-SOD;
Alternate namesextracellular superoxide dismutase [Cu-Zn];
Chromosome4
Map Location4p15.2
EC Number1.15.1.1
SummaryThis gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for SOD3

Proteins

extracellular superoxide dismutase [Cu-Zn] precursor
Refseq ID:NP_003093
Protein GI:118582275
UniProt ID:P08294
mRNA ID:NM_003102
Length:240
RefSeq Status:
MLALLCSCLLLAAGASDAWTGEDSAEPNSDSAEWIRDMYAKVTEIWQEVMQRRDDDGALHAACQVQPSATLDAAQPRVTGVVLFRQLAPRAKLDAFFALE
GFPTEPNSSSRAIHVHQFGDLSQGCESTGPHYNPLAVPHPQHPGDFGNFAVRDGSLWRYRAGLAASLAGPHSIVGRAVVVHAGEDDLGRGGNQASVENGN
AGRRLACCVVGVCGPGLWERQAREHSERKKRRRESECKAA
 
sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1736
peptide sequence: 
MLALLCSCLLLAAGASDA

mat_peptide: 19..240
product: extracellular superoxide dismutase isoform 1
calculated_mol_wt: 24133
peptide sequence: 
WTGEDSAEPNSDSAEWIRDMYAKVTEIWQEVMQRRDDDGALHAACQVQPSATLDAAQPRVTGVVLFRQLAPRAKLDAFFALEGFPTEPNSSSRAIHVHQF
GDLSQGCESTGPHYNPLAVPHPQHPGDFGNFAVRDGSLWRYRAGLAASLAGPHSIVGRAVVVHAGEDDLGRGGNQASVENGNAGRRLACCVVGVCGPGLW
ERQAREHSERKKRRRESECKAA

mat_peptide: 19..227
product: extracellular superoxide dismutase isoform 2
exception: alternative processing
calculated_mol_wt: 22533
peptide sequence: 
WTGEDSAEPNSDSAEWIRDMYAKVTEIWQEVMQRRDDDGALHAACQVQPSATLDAAQPRVTGVVLFRQLAPRAKLDAFFALEGFPTEPNSSSRAIHVHQF
GDLSQGCESTGPHYNPLAVPHPQHPGDFGNFAVRDGSLWRYRAGLAASLAGPHSIVGRAVVVHAGEDDLGRGGNQASVENGNAGRRLACCVVGVCGPGLW
ERQAREHSE
 
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