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MGP002952

UniProt Annotations

Entry Information
Gene Namesuperoxide dismutase 3, extracellular
Protein EntrySODE_HUMAN
UniProt IDP08294
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity2 superoxide + 2 H(+) = O(2) + H(2)O(2).
CofactorName=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence={ECO:0000250}; Note=Binds 1 copper ion per subunit. {ECO:0000250};
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
FunctionProtect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
PolymorphismThe variant Gly-231 which is found in about 2.2% of individual displays a 10-fold increased plasma EC-SOD content due to reduced heparin-binding affinity and thus the impairment of its binding ability to endothelial cell surface.
SimilarityBelongs to the Cu-Zn superoxide dismutase family. {ECO:0000305}.
Subcellular LocationSecreted, extracellular space. Note=99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.
SubunitHomotetramer. {ECO:0000269|PubMed:19289127}.
Tissue SpecificityExpressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/sod3/";
Web ResourceName=Wikipedia; Note=Superoxide dismutase entry; URL="http://en.wikipedia.org/wiki/Superoxide_dismutase";
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