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MGP002963

UniProt Annotations

Entry Information
Gene Namesecreted phosphoprotein 1
Protein EntryOSTP_HUMAN
UniProt IDP10451
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=A; Synonyms=OPN-a, OP1B; IsoId=P10451-1; Sequence=Displayed; Name=B; Synonyms=OPN-b, OP1A; IsoId=P10451-2; Sequence=VSP_003778; Name=C; Synonyms=OPN-c; IsoId=P10451-3; Sequence=VSP_003777; Name=D; IsoId=P10451-4; Sequence=VSP_011639; Name=5; IsoId=P10451-5; Sequence=VSP_043695; Note=No experimental confirmation available.;
FunctionActs as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000250}.
FunctionBinds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
InteractionP16070:CD44; NbExp=2; IntAct=EBI-723648, EBI-490245;
PtmExtensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif. {ECO:0000269|PubMed:15869464, ECO:0000269|PubMed:16807684, ECO:0000269|PubMed:21406692, ECO:0000269|PubMed:22582013}.
PtmN- and O-glycosylated. Isoform 5 is GalNAc O-glycosylated at Thr-59 or Ser-62. {ECO:0000269|PubMed:15869464, ECO:0000269|PubMed:23234360}.
SimilarityBelongs to the osteopontin family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitLigand for integrin alpha-V/beta-3.
Tissue SpecificityBone. Found in plasma.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/SPP1ID42379ch4q22.html";
Web ResourceName=Wikipedia; Note=Osteopontin entry; URL="http://en.wikipedia.org/wiki/Osteopontin";
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