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MGP002971

Record overview

MGPD IDMGP002971
Gene ID6714
SpeciesHomo sapiens (Human)
Gene NameSRC proto-oncogene, non-receptor tyrosine kinase
Gene Symbol SRC
SynonymsASV; SRC1; c-SRC; p60-Src;
Alternate namesproto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog;
Chromosome20
Map Location20q12-q13
EC Number2.7.10.2
SummaryThis gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for SRC

Proteins

proto-oncogene tyrosine-protein kinase Src
Refseq ID:NP_938033
Protein GI:38202217
UniProt ID:P12931
mRNA ID:NM_198291
Length:536
RefSeq Status:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTE
TDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGL
NVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGEN
LVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ
CWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
 
proto-oncogene tyrosine-protein kinase Src
Refseq ID:NP_005408
Protein GI:4885609
UniProt ID:P12931
mRNA ID:NM_005417
Length:536
RefSeq Status:
Protein sequence is identical to GI:38202217 (mRNA isoform)
 
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