MGP Database

MGP002971

Ontology/Pathway Information

Entrez Gene ID	6714
Gene Name	SRC proto-oncogene, non-receptor tyrosine kinase
Gene Symbol	SRC
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005901	IDA:BHF-UCL	C	caveola
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0005856	IEA:UniProtKB-SubCell	C	cytoskeleton
GO:0005829	IDA:UniProtKB	C	cytosol
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0031234	IBA:GO_Central	C	extrinsic component of cytoplasmic side of plasma membrane
GO:0005770	IDA:UniProtKB	C	late endosome
GO:0005764	IDA:UniProtKB	C	lysosome
GO:0005743	IDA:UniProtKB	C	mitochondrial inner membrane
GO:0005739	IDA:UniProtKB	C	mitochondrion
GO:0043005	IEA:Ensembl	C	neuron projection
GO:0005634	IEA:UniProtKB-SubCell	C	nucleus
GO:0005886	IDA:UniProtKB	C	plasma membrane
GO:0014069	IEA:Ensembl	C	postsynaptic density
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0019899	IPI:UniProtKB	F	enzyme binding
GO:0046875	IPI:UniProtKB	F	ephrin receptor binding
GO:0070851	IPI:UniProtKB	F	growth factor receptor binding
GO:0020037	IDA:UniProtKB	F	heme binding
GO:0051427	IBA:GO_Central	F	hormone receptor binding
GO:0005178	TAS:BHF-UCL	F	integrin binding
GO:0044325	IPI:BHF-UCL	F	ion channel binding
GO:0016301	TAS:Reactome	F	kinase activity
GO:0004715	TAS:BHF-UCL	F	non-membrane spanning protein tyrosine kinase activity
GO:0051219	IPI:UniProtKB	F	phosphoprotein binding
GO:0004672	IDA:UniProtKB	F	protein kinase activity
GO:0004713	IDA:UniProtKB	F	protein tyrosine kinase activity
GO:0005102	IPI:UniProtKB	F	receptor binding
GO:0097110	IPI:BHF-UCL	F	scaffold protein binding
GO:0042169	IPI:UniProtKB	F	SH2 domain binding
GO:0005070	TAS:ProtInc	F	SH3/SH2 adaptor activity
GO:0032148	IEA:Ensembl	P	activation of protein kinase B activity
GO:0034332	IEA:Ensembl	P	adherens junction organization
GO:0007411	TAS:Reactome	P	axon guidance
GO:0007596	TAS:Reactome	P	blood coagulation
GO:0045453	ISS:UniProtKB	P	bone resorption
GO:0060444	IEA:Ensembl	P	branching involved in mammary gland duct morphogenesis
GO:0007155	IBA:GO_Central	P	cell adhesion
GO:0007049	IEA:UniProtKB-KW	P	cell cycle
GO:0008283	IEA:Ensembl	P	cell proliferation
GO:0071398	IEA:Ensembl	P	cellular response to fatty acid
GO:0071456	IEA:Ensembl	P	cellular response to hypoxia
GO:0032869	IEA:Ensembl	P	cellular response to insulin stimulus
GO:0071222	IEA:Ensembl	P	cellular response to lipopolysaccharide
GO:0071375	IBA:GO_Central	P	cellular response to peptide hormone stimulus
GO:0071393	ISS:BHF-UCL	P	cellular response to progesterone stimulus
GO:0007417	IBA:GO_Central	P	central nervous system development
GO:0007173	IBA:GO_Central	P	epidermal growth factor receptor signaling pathway
GO:0038096	TAS:Reactome	P	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0008543	TAS:Reactome	P	fibroblast growth factor receptor signaling pathway
GO:0030900	IEA:Ensembl	P	forebrain development
GO:0045087	IBA:GO_Central	P	innate immune response
GO:0007229	IMP:UniProtKB	P	integrin-mediated signaling pathway
GO:0030520	IBA:GO_Central	P	intracellular estrogen receptor signaling pathway
GO:0035556	IDA:BHF-UCL	P	intracellular signal transduction
GO:0050900	TAS:Reactome	P	leukocyte migration
GO:0061024	TAS:Reactome	P	membrane organization
GO:2000811	IMP:UniProtKB	P	negative regulation of anoikis
GO:0043066	IMP:UniProtKB	P	negative regulation of apoptotic process
GO:0043154	IMP:UniProtKB	P	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237	IMP:UniProtKB	P	negative regulation of extrinsic apoptotic signaling pathway
GO:0051895	ISS:BHF-UCL	P	negative regulation of focal adhesion assembly
GO:2001243	IMP:UniProtKB	P	negative regulation of intrinsic apoptotic signaling pathway
GO:0051902	IMP:UniProtKB	P	negative regulation of mitochondrial depolarization
GO:0032463	IMP:UniProtKB	P	negative regulation of protein homooligomerization
GO:0045892	IEA:Ensembl	P	negative regulation of transcription, DNA-templated
GO:0048011	TAS:Reactome	P	neurotrophin TRK receptor signaling pathway
GO:0048477	IEA:Ensembl	P	oogenesis
GO:0036035	IBA:GO_Central	P	osteoclast development
GO:0018105	IEA:Ensembl	P	peptidyl-serine phosphorylation
GO:0038083	IBA:GO_Central	P	peptidyl-tyrosine autophosphorylation
GO:0018108	IDA:MGI	P	peptidyl-tyrosine phosphorylation
GO:0030168	TAS:Reactome	P	platelet activation
GO:0048008	IBA:GO_Central	P	platelet-derived growth factor receptor signaling pathway
GO:0043065	IEA:Ensembl	P	positive regulation of apoptotic process
GO:0090263	IEA:Ensembl	P	positive regulation of canonical Wnt signaling pathway
GO:0045785	IEA:Ensembl	P	positive regulation of cell adhesion
GO:0045737	IEA:Ensembl	P	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0050715	IEA:Ensembl	P	positive regulation of cytokine secretion
GO:2000573	IEA:Ensembl	P	positive regulation of DNA biosynthetic process
GO:0070374	IEA:Ensembl	P	positive regulation of ERK1 and ERK2 cascade
GO:0010907	IEA:Ensembl	P	positive regulation of glucose metabolic process
GO:0046628	IEA:Ensembl	P	positive regulation of insulin receptor signaling pathway
GO:0033625	TAS:BHF-UCL	P	positive regulation of integrin activation
GO:0043406	IEA:Ensembl	P	positive regulation of MAP kinase activity
GO:0043552	IEA:Ensembl	P	positive regulation of phosphatidylinositol 3-kinase activity
GO:0010641	IEA:Ensembl	P	positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0071803	IEA:Ensembl	P	positive regulation of podosome assembly
GO:0031954	IEA:Ensembl	P	positive regulation of protein autophosphorylation
GO:0051897	IMP:UniProtKB	P	positive regulation of protein kinase B signaling
GO:0014911	IEA:Ensembl	P	positive regulation of smooth muscle cell migration
GO:0045893	IEA:Ensembl	P	positive regulation of transcription, DNA-templated
GO:0050847	ISS:BHF-UCL	P	progesterone receptor signaling pathway
GO:0046777	IDA:UniProtKB	P	protein autophosphorylation
GO:0007265	TAS:Reactome	P	Ras protein signal transduction
GO:0045124	TAS:BHF-UCL	P	regulation of bone resorption
GO:2001286	IMP:UniProtKB	P	regulation of caveolin-mediated endocytosis
GO:0022407	IMP:UniProtKB	P	regulation of cell-cell adhesion
GO:0051726	IBA:GO_Central	P	regulation of cell cycle
GO:0042127	IBA:GO_Central	P	regulation of cell proliferation
GO:2000641	IMP:UniProtKB	P	regulation of early endosome to late endosome transport
GO:0010632	IMP:UniProtKB	P	regulation of epithelial cell migration
GO:0033146	IEA:Ensembl	P	regulation of intracellular estrogen receptor signaling pathway
GO:0071801	IBA:GO_Central	P	regulation of podosome assembly
GO:0043393	IEA:Ensembl	P	regulation of protein binding
GO:0043114	TAS:BHF-UCL	P	regulation of vascular permeability
GO:0010447	IEA:Ensembl	P	response to acidic pH
GO:0042493	IEA:Ensembl	P	response to drug
GO:0051602	IEA:Ensembl	P	response to electrical stimulus
GO:0042542	IEA:Ensembl	P	response to hydrogen peroxide
GO:0070555	IMP:BHF-UCL	P	response to interleukin-1
GO:0009612	IEA:Ensembl	P	response to mechanical stimulus
GO:0051385	IEA:Ensembl	P	response to mineralocorticoid
GO:0031667	IEA:Ensembl	P	response to nutrient levels
GO:0009615	IEA:Ensembl	P	response to virus
GO:0007172	TAS:ProtInc	P	signal complex assembly
GO:0007165	TAS:ProtInc	P	signal transduction
GO:0016337	IEA:Ensembl	P	single organismal cell-cell adhesion
GO:0043149	IMP:UniProtKB	P	stress fiber assembly
GO:0031295	TAS:Reactome	P	T cell costimulation
GO:0045056	IEA:Ensembl	P	transcytosis
GO:0007179	IMP:UniProtKB	P	transforming growth factor beta receptor signaling pathway
GO:0060065	IEA:Ensembl	P	uterus development
GO:0016032	IEA:UniProtKB-KW	P	viral process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_115755	Signaling by ERBB2
REACT_111102	Signal Transduction