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MGP002972

UniProt Annotations

Entry Information
Gene Namesteroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
Protein EntryS5A1_HUMAN
UniProt IDP18405
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimally active at alkaline pHs.;
Catalytic ActivityA 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo- Delta(4)-steroid + NADPH.
FunctionConverts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
InductionIts expression is regulated by androgens such as testosterone.
SimilarityBelongs to the steroid 5-alpha reductase family. {ECO:0000305}.
Subcellular LocationMicrosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityLiver and prostate (at a low level).
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/srd5a1/";
Web ResourceName=Wikipedia; Note=5-alpha reductase entry; URL="http://en.wikipedia.org/wiki/5_alpha_reductase";
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