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MGP003013

Record overview

MGPD IDMGP003013
Gene ID6790
SpeciesHomo sapiens (Human)
Gene Nameaurora kinase A
Gene Symbol AURKA
SynonymsAIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; PPP1R47;
Alternate namesaurora kinase A; ARK-1; Aurora-A kinase; IPL1-related kinase; aurora 2; aurora-related kinase 1; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; breast tumor-amplified kinase; breast-tumor-amplified kinase; hARK1; protein phosphatase 1, regulatory subunit 47; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine-protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase aurora-A;
Chromosome20
Map Location20q13
EC Number2.7.11.1
SummaryThe protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for AURKA

Proteins

aurora kinase A
Refseq ID:NP_003591
Protein GI:38327562
UniProt ID:O14965
mRNA ID:NM_003600
Length:403
RefSeq Status:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQ
PLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYF
HDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESAS
KQS
 
aurora kinase A
Refseq ID:NP_940839
Protein GI:38327572
UniProt ID:O14965
mRNA ID:NM_198437
Length:403
RefSeq Status:
Protein sequence is identical to GI:38327562 (mRNA isoform)
 
aurora kinase A
Refseq ID:NP_940838
Protein GI:38327570
UniProt ID:O14965
mRNA ID:NM_198436
Length:403
RefSeq Status:
Protein sequence is identical to GI:38327562 (mRNA isoform)
 
aurora kinase A
Refseq ID:NP_940836
Protein GI:38327566
UniProt ID:O14965
mRNA ID:NM_198434
Length:403
RefSeq Status:
Protein sequence is identical to GI:38327562 (mRNA isoform)
 
aurora kinase A
Refseq ID:NP_940835
Protein GI:38327564
UniProt ID:O14965
mRNA ID:NM_198433
Length:403
RefSeq Status:
Protein sequence is identical to GI:38327562 (mRNA isoform)
 
aurora kinase A
Refseq ID:NP_940837
Protein GI:38327568
UniProt ID:O14965
mRNA ID:NM_198435
Length:403
RefSeq Status:
Protein sequence is identical to GI:38327562 (mRNA isoform)
 
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