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MGP003016

Record overview

MGPD IDMGP003016
Gene ID6804
SpeciesHomo sapiens (Human)
Gene Namesyntaxin 1A (brain)
Gene Symbol STX1A
SynonymsSTX1; HPC-1; P35-1; SYN1A;
Alternate namessyntaxin-1A; neuron-specific antigen HPC-1;
Chromosome7
Map Location7q11.23
SummaryThis gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
OrthologsView orthologs and multiple alignments for STX1A

Proteins

syntaxin-1A isoform 1
Refseq ID:NP_004594
Protein GI:4759182
UniProt ID:Q16623
mRNA ID:NM_004603
Length:288
RefSeq Status:
MKDRTQELRTAKDSDDDDDVAVTVDRDRFMDEFFEQVEEIRGFIDKIAENVEEVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSI
EQEEGLNRSSADLRIRKTQHSTLSRKFVEVMSEYNATQSDYRERCKGRIQRQLEITGRTTTSEELEDMLESGNPAIFASGIIMDSSISKQALSEIETRHS
EIIKLENSIRELHDMFMDMAMLVESQGEMIDRIEYNVEHAVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVILGIVIASTVGGIFA
 
syntaxin-1A isoform 2
Refseq ID:NP_001159375
Protein GI:259906442
UniProt ID:Q16623
mRNA ID:NM_001165903
Length:251
RefSeq Status:
MKDRTQELRTAKDSDDDDDVAVTVDRDRFMDEFFEQVEEIRGFIDKIAENVEEVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSI
EQEEGLNRSSADLRIRKTQHSTLSRKFVEVMSEYNATQSDYRERCKGRIQRQLEITGRTTTSEELEDMLESGNPAIFASGIIMDSSISKQALSEIETRHS
EIIKLENSIRELHDMFMDMAMLVESQTMWRGPCLTPRRPSSTRARRAGRKS
 
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