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MGP003021

UniProt Annotations

Entry Information
Gene Namesulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
Protein EntryST1A3_HUMAN
UniProt IDP0DMM9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P0DMM9-1; Sequence=Displayed; Name=2; IsoId=P0DMM9-2; Sequence=VSP_012326; Note=No experimental confirmation available. Ref.10 (BAC85507) sequence differs from that shown due to a frameshift in position 101. {ECO:0000305}; Name=3; IsoId=P0DMM9-3; Sequence=VSP_047771;
Catalytic Activity3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate.
CautionFound in a segmental duplication on p arm of chromosome 16 giving rise to two identical copies of this gene sharing exons with SLX1A and SLX1B. The ORFs of SULT1A3 and SULT1A4 differ with only a single nucleotide change that does not alter the encoded amino acid. It is not possible to determine whether any individual polymorphism is present within SULT1A3 or SULT1A4 (PubMed:15358107). {ECO:0000305|PubMed:15358107}.
FunctionSulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.
PtmThe N-terminus is blocked.
SimilarityBelongs to the sulfotransferase 1 family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000269|PubMed:16083857}.
Tissue SpecificityLiver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte.
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