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MGP003039

UniProt Annotations

Entry Information
Gene Namesynaptotagmin I
Protein EntrySYT1_HUMAN
UniProt IDP21579
SpeciesHuman
Comments
Comment typeDescription
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. {ECO:0000250};
DomainThe first C2 domain mediates Ca(2+)-dependent phospholipid binding.
DomainThe second C2 domain mediates interaction with SV2A and STN2. {ECO:0000250}.
FunctionMay have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
InteractionO00305-2:CACNB4; NbExp=2; IntAct=EBI-524909, EBI-714855; Q9Y6K9:IKBKG; NbExp=3; IntAct=EBI-524909, EBI-81279;
SimilarityBelongs to the synaptotagmin family. {ECO:0000305}.
SimilarityContains 2 C2 domains. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Subcellular LocationCytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules.
SubunitHomotetramer (Probable). Interacts with SCAMP5, STON2, SV2A, SV2B, SV2C and RIMS1. Forms a complex with SV2B, syntaxin 1 and SNAP25 (By similarity). {ECO:0000250, ECO:0000305}.
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