MGP Database

MGP003041

Record overview

MGPD ID	MGP003041
Gene ID	6863
Species	Homo sapiens (Human)
Gene Name	tachykinin, precursor 1
Gene Symbol	TAC1
Synonyms	NK2; NPK; NKNA; TAC2; Hs.2563;
Alternate names	protachykinin-1; PPT; neurokinin 1; neurokinin 2; neurokinin A; neurokinin alpha; neuromedin L; neuropeptide K; neuropeptide gamma; preprotachykinin; substance K; substance P; tachykinin 2; tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma);
Chromosome	7
Map Location	7q21-q22
Summary	This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Orthologs	View orthologs and multiple alignments for TAC1

Proteins

protachykinin-1 isoform alpha precursor

Refseq ID:	NP_054702
Protein GI:	7770075
UniProt ID:	P20366
mRNA ID:	NM_013996
Length:	111
RefSeq Status:

`MKILVALAVFFLVSTQLFAEEIGANDDLNYWSDWYDSDQIKEELPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKMAYE RSAMQNYERRR`

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2112
peptide sequence: 
MKILVALAVFFLVSTQLFA

mat_peptide: 58..68
product: substance P
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12074933]
calculated_mol_wt: 1349
peptide sequence: 
RPKPQQFFGLM

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2112
peptide sequence: 
MKILVALAVFFLVSTQLFA

mat_peptide: 58..68
product: substance P
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12074933]
calculated_mol_wt: 1349
peptide sequence: 
RPKPQQFFGLM

protachykinin-1 isoform beta precursor

Refseq ID:	NP_003173
Protein GI:	4507341
UniProt ID:	P20366
mRNA ID:	NM_003182
Length:	129
RefSeq Status:

`MKILVALAVFFLVSTQLFAEEIGANDDLNYWSDWYDSDQIKEELPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKRHKT DSFVGLMGKRALNSVAYERSAMQNYERRR`

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2112
peptide sequence: 
MKILVALAVFFLVSTQLFA

mat_peptide: 58..68
product: substance P
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12074933]
calculated_mol_wt: 1349
peptide sequence: 
RPKPQQFFGLM

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2112
peptide sequence: 
MKILVALAVFFLVSTQLFA

mat_peptide: 58..68
product: substance P
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12074933]
calculated_mol_wt: 1349
peptide sequence: 
RPKPQQFFGLM

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2112
peptide sequence: 
MKILVALAVFFLVSTQLFA

mat_peptide: 58..68
product: substance P
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12074933]
calculated_mol_wt: 1349
peptide sequence: 
RPKPQQFFGLM

mat_peptide: 72..92
product: neuropeptide gamma
calculated_mol_wt: 2322
peptide sequence: 
DAGHGQISHKRHKTDSFVGLM

mat_peptide: 83..92
product: neurokinin A
calculated_mol_wt: 1134
peptide sequence: 
HKTDSFVGLM

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2112
peptide sequence: 
MKILVALAVFFLVSTQLFA

mat_peptide: 58..68
product: substance P
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12074933]
calculated_mol_wt: 1349
peptide sequence: 
RPKPQQFFGLM

mat_peptide: 72..107
product: neuropeptide K
calculated_mol_wt: 3982
peptide sequence: 
DADSSIEKQVALLKALYGHGQISHKRHKTDSFVGLM

mat_peptide: 98..107
product: neurokinin A
calculated_mol_wt: 1134
peptide sequence: 
HKTDSFVGLM

protachykinin-1 isoform delta precursor

Refseq ID:	NP_054704
Protein GI:	7770079
UniProt ID:	P20366
mRNA ID:	NM_013998
Length:	96
RefSeq Status:

`MKILVALAVFFLVSTQLFAEEIGANDDLNYWSDWYDSDQIKEELPEPFEHLLQRIARRPKPQQFFGLMGKRDAGHGQISHKMAYERSAMQNYERRR`

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2112
peptide sequence: 
MKILVALAVFFLVSTQLFA

mat_peptide: 58..68
product: substance P
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12074933]
calculated_mol_wt: 1349
peptide sequence: 
RPKPQQFFGLM

protachykinin-1 isoform gamma precursor

Refseq ID:	NP_054703
Protein GI:	7770077
UniProt ID:	P20366
mRNA ID:	NM_013997
Length:	114
RefSeq Status:

`MKILVALAVFFLVSTQLFAEEIGANDDLNYWSDWYDSDQIKEELPEPFEHLLQRIARRPKPQQFFGLMGKRDAGHGQISHKRHKTDSFVGLMGKRALNSV AYERSAMQNYERRR`

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2112
peptide sequence: 
MKILVALAVFFLVSTQLFA

mat_peptide: 58..68
product: substance P
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12074933]
calculated_mol_wt: 1349
peptide sequence: 
RPKPQQFFGLM

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2112
peptide sequence: 
MKILVALAVFFLVSTQLFA

mat_peptide: 58..68
product: substance P
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12074933]
calculated_mol_wt: 1349
peptide sequence: 
RPKPQQFFGLM

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2112
peptide sequence: 
MKILVALAVFFLVSTQLFA

mat_peptide: 58..68
product: substance P
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12074933]
calculated_mol_wt: 1349
peptide sequence: 
RPKPQQFFGLM

mat_peptide: 72..92
product: neuropeptide gamma
calculated_mol_wt: 2322
peptide sequence: 
DAGHGQISHKRHKTDSFVGLM

mat_peptide: 83..92
product: neurokinin A
calculated_mol_wt: 1134
peptide sequence: 
HKTDSFVGLM