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MGP003041

UniProt Annotations

Entry Information
Gene Nametachykinin, precursor 1
Protein EntryTKN1_HUMAN
UniProt IDP20366
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=Beta; IsoId=P20366-1; Sequence=Displayed; Name=Alpha; IsoId=P20366-2; Sequence=VSP_006376, VSP_006377; Name=Gamma; IsoId=P20366-3; Sequence=VSP_006375; Name=Delta; IsoId=P20366-4; Sequence=VSP_006375, VSP_006376, VSP_006377;
FunctionTachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
InteractionP25103:TACR1; NbExp=2; IntAct=EBI-6655360, EBI-6655287; P21452:TACR2; NbExp=2; IntAct=EBI-6655449, EBI-6655413;
PtmThe substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro). {ECO:0000269|PubMed:21314817}.
SimilarityBelongs to the tachykinin family. {ECO:0000305}.
Subcellular LocationSecreted.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TAC1ID44483ch7q21.html";
Web ResourceName=Wikipedia; Note=Neurokinin-1 entry; URL="http://en.wikipedia.org/wiki/Neurokinin_1";
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