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MGP003055

UniProt Annotations

Entry Information
Gene NameTAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
Protein EntryTAF10_HUMAN
UniProt IDQ12962
SpeciesHuman
Comments
Comment typeDescription
DomainThe [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.
FunctionTAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
InteractionO15265:ATXN7; NbExp=6; IntAct=EBI-708376, EBI-708350; Q8WTS6:SETD7; NbExp=2; IntAct=EBI-708376, EBI-1268586;
PtmMonomethylated at Lys-189 by SETD7, leading to increase its affinity for RNA polymerase II.
SimilarityBelongs to the TAF10 family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9674425}.
SubunitTFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, SUPT3H, TAF5L TAF6L, TAF9, TAF10, TAF12 and TRRAP. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Interacts with TAF3. {ECO:0000269|PubMed:10373431, ECO:0000269|PubMed:11438666, ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:12601814, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:9674425, ECO:0000269|PubMed:9885574}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/taf10/";
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