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MGP003066

Record overview

MGPD IDMGP003066
Gene ID6898
SpeciesHomo sapiens (Human)
Gene Nametyrosine aminotransferase
Gene Symbol TAT
Alternate namestyrosine aminotransferase; L-tyrosine:2-oxoglutarate aminotransferase; tyrosine aminotransferase, cytosolic;
Chromosome16
Map Location16q22.1
EC Number2.6.1.5
SummaryThis nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for TAT

Proteins

tyrosine aminotransferase
Refseq ID:NP_000344
Protein GI:4507369
UniProt ID:P17735
mRNA ID:NM_000353
Length:454
RefSeq Status:
MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAKKTFNPIRAIVDNMKVKPNPNKTMISLSIGDPTVFGNLPTDPEVTQAMKDA
LDSGKYNGYAPSIGFLSSREEIASYYHCPEAPLEAKDVILTSGCSQAIDLCLAVLANPGQNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKSWEIDLKQ
LEYLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSDCKYEPLATLSTDVPILSCGGLAKRWLVPGWRLGWILIHDRRDI
FGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNADLCYGALAAIPGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQ
SVHCLPATCFEYPNFIRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK
 
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