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MGP003066

UniProt Annotations

Entry Information
Gene Nametyrosine aminotransferase
Protein EntryATTY_HUMAN
UniProt IDP17735
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityL-tyrosine + 2-oxoglutarate = 4- hydroxyphenylpyruvate + L-glutamate. {ECO:0000269|PubMed:16640556, ECO:0000269|PubMed:7999802}.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
DiseaseTyrosinemia 2 (TYRSN2) [MIM:276600]: An inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation. {ECO:0000269|PubMed:1357662}. Note=The disease is caused by mutations affecting the gene represented in this entry.
FunctionTransaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. {ECO:0000269|PubMed:16640556, ECO:0000269|PubMed:7999802}.
PathwayAmino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.
SimilarityBelongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
SubunitHomodimer. {ECO:0000305|Ref.7}.
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