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MGP003073

UniProt Annotations

Entry Information
Gene Nametransducin (beta)-like 1X-linked
Protein EntryTBL1X_HUMAN
UniProt IDO60907
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60907-1; Sequence=Displayed; Name=2; IsoId=O60907-2; Sequence=VSP_036905;
DomainThe F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes. {ECO:0000250}.
FunctionF-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. {ECO:0000269|PubMed:14980219}.
SimilarityBelongs to the WD repeat EBI family. {ECO:0000305}.
SimilarityContains 1 F-box-like domain. {ECO:0000305}.
SimilarityContains 1 LisH domain. {ECO:0000255|PROSITE- ProRule:PRU00126}.
SimilarityContains 8 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}.
Subcellular LocationNucleus {ECO:0000305}.
SubunitComponent of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Probably part of other corepressor complexes, that do not contain NCOR1 and NCOR2. Interacts with histones H2B, H3a and H4. {ECO:0000269|PubMed:11389839}.
Tissue SpecificityUbiquitous. {ECO:0000269|PubMed:10330347}.
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