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MGP003090

Record overview

MGPD IDMGP003090
Gene ID6944
SpeciesHomo sapiens (Human)
Gene Namevacuolar protein sorting 72 homolog (S. cerevisiae)
Gene Symbol VPS72
SynonymsYL1; CFL1; Swc2; YL-1; TCFL1;
Alternate namesvacuolar protein sorting-associated protein 72 homolog; transcription factor-like 1; transformation suppressor gene YL-1;
Chromosome1
Map Location1q21
SummaryThe protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
OrthologsView orthologs and multiple alignments for VPS72

Proteins

vacuolar protein sorting-associated protein 72 homolog isoform 1
Refseq ID:NP_001258016
Protein GI:402793870
UniProt ID:Q15906
mRNA ID:NM_001271087
Length:375
RefSeq Status:
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRK
VNTPAGSSQKAREEKALLPLELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEADKKKQ
VHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGSLCFSLSFVLRLDPAPSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVR
EVCPVTHRPALYRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQKIVIK
 
vacuolar protein sorting-associated protein 72 homolog isoform 2
Refseq ID:NP_005988
Protein GI:5174715
UniProt ID:Q15906
mRNA ID:NM_005997
Length:364
RefSeq Status:
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRK
VNTPAGSSQKAREEKALLPLELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYERLEADKKKQ
VHKKRKCPGPIITYHSVTVPLVGEPGPKEENVDIEGLDPAPSVSALTPHAGTGPVNPPARCSRTFITFSDDATFEEWFPQGRPPKVPVREVCPVTHRPAL
YRDPVTDIPYATARAFKIIREAYKKYITAHGLPPTASALGPGPPPPEPLPGSGPRALRQKIVIK
 
vacuolar protein sorting-associated protein 72 homolog isoform 3
Refseq ID:NP_001258017
Protein GI:402794631
UniProt ID:
mRNA ID:NM_001271088
Length:199
RefSeq Status:
MSLAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGDEPSSDGEAEEPRRKRRVVTKAYKEPLKSLRPRK
VNTPAGSSQKAREEKALLPLELQDDGSDSRKSMRQSTAEHTRQTFLRVQERQGQSRRRKGPHCERPLTQEELLREAKITEELNLRSLETYEAAPKSPCS
 
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