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MGP003090

UniProt Annotations

Entry Information
Gene Namevacuolar protein sorting 72 homolog (S. cerevisiae)
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15906-1; Sequence=Displayed; Name=2; IsoId=Q15906-2; Sequence=VSP_047566; Note=No experimental confirmation available.;
FunctionCould be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling.
InteractionQ9Y265:RUVBL1; NbExp=6; IntAct=EBI-399189, EBI-353675;
SimilarityBelongs to the VPS72/YL1 family. {ECO:0000305}.
Subcellular LocationNucleus.
SubunitComponent of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds to H2AFZ/H2AZ. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:15647280}.
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