MGP Database

MGP003092

Record overview

MGPD ID	MGP003092
Gene ID	6947
Species	Homo sapiens (Human)
Gene Name	transcobalamin I (vitamin B12 binding protein, R binder family)
Gene Symbol	TCN1
Synonyms	HC; TC1; TCI; TC-1;
Alternate names	transcobalamin-1; haptocorin; haptocorrin; protein R;
Chromosome	11
Map Location	11q11-q12
Summary	This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for TCN1

Proteins

transcobalamin-1 precursor

Refseq ID:	NP_001053
Protein GI:	21071008
UniProt ID:	P20061
mRNA ID:	NM_001062
Length:	433
RefSeq Status:

MRQSHQLPLVGLLLFSFIPSQLCEICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIIL
ALGVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKK
SLINGQIKADEGSLKNISIYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQGAFSNPNAAAQVLPALMGKTFL
DINKDSSCVSASGNFNISADEPITVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGLCANNNDRT
YWELLSGGEPLSQGAGSYVVRNGENLEVRWSKY

sig_peptide: 1..23
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2628
peptide sequence: 
MRQSHQLPLVGLLLFSFIPSQLC

mat_peptide: 24..433
product: transcobalamin-1
calculated_mol_wt: 45597
peptide sequence: 
EICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIILALGVCRNAEENLIYDYHLIDKLE
NKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKS
LVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPI
TVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQGAGSYVVRNG
ENLEVRWSKY