MGP Database

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MGP003092

UniProt Annotations

Entry Information
Gene Nametranscobalamin I (vitamin B12 binding protein, R binder family)
Protein EntryTCO1_HUMAN
UniProt IDP20061
SpeciesHuman
Comments
Comment typeDescription
FunctionBinds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.
PtmContains about 30% carbohydrates.
SimilarityBelongs to the eukaryotic cobalamin transport proteins family. {ECO:0000305}.
Subcellular LocationSecreted.
Tissue SpecificityProduced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils. {ECO:0000269|PubMed:2777761}.
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