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MGP003098

Record overview

MGPD IDMGP003098
Gene ID6999
SpeciesHomo sapiens (Human)
Gene Nametryptophan 2,3-dioxygenase
Gene Symbol TDO2
SynonymsTO; TDO; TPH2; TRPO;
Alternate namestryptophan 2,3-dioxygenase; TDO; TDO2; TO; TRPO; tryptamin 2,3-dioxygenase; tryptophan oxygenase; tryptophan pyrrolase; tryptophanase;
Chromosome4
Map Location4q31-q32
EC Number1.13.11.11
SummaryThis gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]
OrthologsView orthologs and multiple alignments for TDO2

Proteins

tryptophan 2,3-dioxygenase
Refseq ID:NP_005642
Protein GI:5032165
UniProt ID:P48775
mRNA ID:NM_005651
Length:406
RefSeq Status:
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNG
HVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKT
LLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYF
SSDESD
 
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