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MGP003098

UniProt Annotations

Entry Information
Gene Nametryptophan 2,3-dioxygenase
Protein EntryT23O_HUMAN
UniProt IDP48775
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityL-tryptophan + O(2) = N-formyl-L-kynurenine. {ECO:0000255|HAMAP-Rule:MF_03020}.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000255|HAMAP-Rule:MF_03020}; Note=Binds 2 heme groups per tetramer. {ECO:0000255|HAMAP- Rule:MF_03020};
FunctionIncorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity). {ECO:0000250}.
PathwayAmino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. {ECO:0000255|HAMAP-Rule:MF_03020}.
SimilarityBelongs to the tryptophan 2,3-dioxygenase family. {ECO:0000255|HAMAP-Rule:MF_03020}.
SubunitHomotetramer. {ECO:0000255|HAMAP-Rule:MF_03020}.
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