MGP Database

MGP003115

Record overview

MGPD ID	MGP003115
Gene ID	7035
Species	Homo sapiens (Human)
Gene Name	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Gene Symbol	TFPI
Synonyms	EPI; TFI; LACI; TFPI1;
Alternate names	tissue factor pathway inhibitor; anti-convertin; extrinsic pathway inhibitor;
Chromosome	2
Map Location	2q32
Summary	This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for TFPI

Proteins

tissue factor pathway inhibitor isoform a precursor

Refseq ID:	NP_006278
Protein GI:	5454114
UniProt ID:	P10646
mRNA ID:	NM_006287
Length:	304
RefSeq Status:

`MIYTMKKVHALWASVCLLLNLAPAPLNADSEEDEEHTIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEEC KKMCTRDNANRIIKTTLQQEKPDFCFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPNGFQVDNYGTQLNAVNNSLTP QSTKVPSLFEFHGPSWCLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKGFIQRISKGGLIKTKRKRKKQRVKIAYEEIF VKNM`

sig_peptide: 1..28
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3083
peptide sequence: 
MIYTMKKVHALWASVCLLLNLAPAPLNA

mat_peptide: 29..304
product: tissue factor pathway inhibitor isoform a
calculated_mol_wt: 31951
peptide sequence: 
DSEEDEEHTIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRDNANRIIKTTLQQEKPDFCFLE
EDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPNGFQVDNYGTQLNAVNNSLTPQSTKVPSLFEFHGPSWCLTPADRGLCRA
NENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKGFIQRISKGGLIKTKRKRKKQRVKIAYEEIFVKNM

tissue factor pathway inhibitor isoform b precursor

Refseq ID:	NP_001027452
Protein GI:	73760409
UniProt ID:	P10646
mRNA ID:	NM_001032281
Length:	251
RefSeq Status:

`MIYTMKKVHALWASVCLLLNLAPAPLNADSEEDEEHTIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEEC KKMCTRDNANRIIKTTLQQEKPDFCFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPNGFQVDNYGTQLNAVNNSLTP QSTKVPSLFVTKEGTNDGWKNAAHIYQVFLNAFCIHASMFFLGLDSISCLC`

sig_peptide: 1..28
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3083
peptide sequence: 
MIYTMKKVHALWASVCLLLNLAPAPLNA

mat_peptide: 29..304
product: tissue factor pathway inhibitor isoform a
calculated_mol_wt: 31951
peptide sequence: 
DSEEDEEHTIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRDNANRIIKTTLQQEKPDFCFLE
EDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPNGFQVDNYGTQLNAVNNSLTPQSTKVPSLFEFHGPSWCLTPADRGLCRA
NENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKGFIQRISKGGLIKTKRKRKKQRVKIAYEEIFVKNM

sig_peptide: 1..28
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3083
peptide sequence: 
MIYTMKKVHALWASVCLLLNLAPAPLNA

mat_peptide: 29..251
product: tissue factor pathway inhibitor isoform b
calculated_mol_wt: 25588
peptide sequence: 
DSEEDEEHTIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRDNANRIIKTTLQQEKPDFCFLE
EDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPNGFQVDNYGTQLNAVNNSLTPQSTKVPSLFVTKEGTNDGWKNAAHIYQV
FLNAFCIHASMFFLGLDSISCLC