MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003115

UniProt Annotations

Entry Information
Gene Nametissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Protein EntryTFPI1_HUMAN
UniProt IDP10646
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=Alpha; Synonyms=TFPIalpha; IsoId=P10646-1; Sequence=Displayed; Name=Beta; Synonyms=TFPIbeta; IsoId=P10646-2; Sequence=VSP_003030, VSP_003031; Note=GPI-anchored.;
DomainThis inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa.
FunctionInhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
PtmO-glycosylated. {ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19017259, ECO:0000269|PubMed:8639592}.
SimilarityContains 3 BPTI/Kunitz inhibitor domains. {ECO:0000255|PROSITE-ProRule:PRU00031}.
Subcellular LocationIsoform Alpha: Secreted.
Subcellular LocationIsoform Beta: Microsome membrane {ECO:0000269|PubMed:22144186}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:22144186}.
Tissue SpecificityMostly in endothelial cells.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/tfpi/";
Web ResourceName=Wikipedia; Note=TFPI entry; URL="http://en.wikipedia.org/wiki/TFPI";
  logo