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MGP003118

Record overview

MGPD IDMGP003118
Gene ID7040
SpeciesHomo sapiens (Human)
Gene Nametransforming growth factor, beta 1
Gene Symbol TGFB1
SynonymsCED; LAP; DPD1; TGFB; TGFbeta;
Alternate namestransforming growth factor beta-1; TGF-beta-1; latency-associated peptide; prepro-transforming growth factor beta-1;
Chromosome19
Map Location19q13.1
SummaryThis gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009]
OrthologsView orthologs and multiple alignments for TGFB1

Proteins

transforming growth factor beta-1 precursor
Refseq ID:NP_000651
Protein GI:63025222
UniProt ID:P01137
mRNA ID:NM_000660
Length:390
RefSeq Status:
MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPE
ADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDV
TGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI
DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
 
sig_peptide: 1..29
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3076
peptide sequence: 
MPPSGLRLLPLLLPLLWLLVLTPGRPAAG

mat_peptide: 30..278
product: Latency-associated peptide
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P01137.2)
calculated_mol_wt: 28491
peptide sequence: 
LSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTH
SIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRD
NTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRR

mat_peptide: 279..390
product: Transforming growth factor beta-1
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P01137.2)
calculated_mol_wt: 12795
peptide sequence: 
ALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQ
LSNMIVRSCKCS
 
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