MGP Database

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MGP003118

Ontology/Pathway Information

Entrez Gene ID7040
Gene Nametransforming growth factor, beta 1
Gene Symbol TGFB1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030424 IEA:EnsemblCaxon
GO:0072562 IDA:UniProtKBCblood microparticle
GO:0009986 IMP:BHF-UCLCcell surface
GO:0005737 IDA:BHF-UCLCcytoplasm
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0005796 TAS:ReactomeCGolgi lumen
GO:0043025 IEA:EnsemblCneuronal cell body
GO:0005634 IDA:BHF-UCLCnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0005578 ISS:UniProtKBCproteinaceous extracellular matrix
GO:0003823 IPI:UniProtKBFantigen binding
GO:0005125 TAS:AgBaseFcytokine activity
GO:0019899 IPI:BHF-UCLFenzyme binding
GO:0001948 IPI:UniProtKBFglycoprotein binding
GO:0005114 IDA:BHF-UCLFtype II transforming growth factor beta receptor binding
GO:0046732 TAS:ReactomePactive induction of host immune response by virus
GO:0002460 IEA:EnsemblPadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0007568 IEA:EnsemblPaging
GO:0006754 IDA:BHF-UCLPATP biosynthetic process
GO:0007596 TAS:ReactomePblood coagulation
GO:0060751 IEA:EnsemblPbranch elongation involved in mammary gland duct branching
GO:0045216 IDA:BHF-UCLPcell-cell junction organization
GO:0007050 IDA:BHF-UCLPcell cycle arrest
GO:0016049 IEA:InterProPcell growth
GO:0006874 IEA:EnsemblPcellular calcium ion homeostasis
GO:0071549 IEA:EnsemblPcellular response to dexamethasone stimulus
GO:0071407 IDA:UniProtKBPcellular response to organic cyclic compound
GO:0071560 IDA:BHF-UCLPcellular response to transforming growth factor beta stimulus
GO:0002062 IDA:UniProtKBPchondrocyte differentiation
GO:0007182 IDA:UniProtKBPcommon-partner SMAD protein phosphorylation
GO:0002248 TAS:BHF-UCLPconnective tissue replacement involved in inflammatory response wound healing
GO:0009817 IEA:EnsemblPdefense response to fungus, incompatible interaction
GO:0048565 IEA:EnsemblPdigestive tract development
GO:0007492 IEA:EnsemblPendoderm development
GO:0007173 IDA:BHF-UCLPepidermal growth factor receptor signaling pathway
GO:0001837 IEA:EnsemblPepithelial to mesenchymal transition
GO:0019049 IDA:BHF-UCLPevasion or tolerance of host defenses by virus
GO:0085029 IDA:BHF-UCLPextracellular matrix assembly
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0097191 IDA:BHF-UCLPextrinsic apoptotic signaling pathway
GO:0060325 IEA:EnsemblPface morphogenesis
GO:0007565 IEA:EnsemblPfemale pregnancy
GO:0060364 IEA:EnsemblPfrontal suture morphogenesis
GO:0008354 IEA:EnsemblPgerm cell migration
GO:0002244 IDA:UniProtKBPhematopoietic progenitor cell differentiation
GO:0030214 IDA:UniProtKBPhyaluronan catabolic process
GO:0006954 IDA:UniProtKBPinflammatory response
GO:0048839 IEA:EnsemblPinner ear development
GO:0070306 IEA:EnsemblPlens fiber cell differentiation
GO:0031663 IDA:UniProtKBPlipopolysaccharide-mediated signaling pathway
GO:0048535 ISS:UniProtKBPlymph node development
GO:0010742 IC:BHF-UCLPmacrophage derived foam cell differentiation
GO:0060744 IEA:EnsemblPmammary gland branching involved in thelarche
GO:0000165 IMP:UniProtKBPMAPK cascade
GO:0007093 IDA:BHF-UCLPmitotic cell cycle checkpoint
GO:0019048 TAS:ReactomePmodulation by virus of host morphology or physiology
GO:0032943 IEA:EnsemblPmononuclear cell proliferation
GO:0042552 IEA:EnsemblPmyelination
GO:0043011 IEA:EnsemblPmyeloid dendritic cell differentiation
GO:0043537 IDA:BHF-UCLPnegative regulation of blood vessel endothelial cell migration
GO:0022408 IDA:BHF-UCLPnegative regulation of cell-cell adhesion
GO:0045786 IDA:HGNCPnegative regulation of cell cycle
GO:0030308 IDA:BHF-UCLPnegative regulation of cell growth
GO:0008285 IDA:BHF-UCLPnegative regulation of cell proliferation
GO:0008156 IMP:BHF-UCLPnegative regulation of DNA replication
GO:0050680 IDA:BHF-UCLPnegative regulation of epithelial cell proliferation
GO:0010716 IC:BHF-UCLPnegative regulation of extracellular matrix disassembly
GO:0045599 IDA:UniProtKBPnegative regulation of fat cell differentiation
GO:0010629 IDA:BHF-UCLPnegative regulation of gene expression
GO:1900126 IDA:UniProtKBPnegative regulation of hyaluronan biosynthetic process
GO:0010936 IDA:DFLATPnegative regulation of macrophage cytokine production
GO:0045930 IDA:BHF-UCLPnegative regulation of mitotic cell cycle
GO:0045662 IDA:UniProtKBPnegative regulation of myoblast differentiation
GO:0007406 IEA:EnsemblPnegative regulation of neuroblast proliferation
GO:0030279 IEA:EnsemblPnegative regulation of ossification
GO:0050765 IEA:EnsemblPnegative regulation of phagocytosis
GO:0001933 IDA:BHF-UCLPnegative regulation of protein phosphorylation
GO:0051280 IEA:EnsemblPnegative regulation of release of sequestered calcium ion into cytosol
GO:0048642 IDA:UniProtKBPnegative regulation of skeletal muscle tissue development
GO:0042130 IEA:EnsemblPnegative regulation of T cell proliferation
GO:0045892 IDA:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0000122 IEA:EnsemblPnegative regulation of transcription from RNA polymerase II promoter
GO:0030512 TAS:ReactomePnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0031100 IEA:EnsemblPorgan regeneration
GO:0043932 IEP:BHF-UCLPossification involved in bone remodeling
GO:0060389 IDA:BHF-UCLPpathway-restricted SMAD protein phosphorylation
GO:0006796 IDA:BHF-UCLPphosphate-containing compound metabolic process
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0043065 IEA:EnsemblPpositive regulation of apoptotic process
GO:0043536 IDA:BHF-UCLPpositive regulation of blood vessel endothelial cell migration
GO:0030501 IEP:BHF-UCLPpositive regulation of bone mineralization
GO:0090190 IEA:EnsemblPpositive regulation of branching involved in ureteric bud morphogenesis
GO:0071158 IEA:EnsemblPpositive regulation of cell cycle arrest
GO:0030335 IDA:BHF-UCLPpositive regulation of cell migration
GO:0008284 IDA:BHF-UCLPpositive regulation of cell proliferation
GO:0032270 IDA:BHF-UCLPpositive regulation of cellular protein metabolic process
GO:0050921 IDA:BHF-UCLPpositive regulation of chemotaxis
GO:0032967 IDA:BHF-UCLPpositive regulation of collagen biosynthetic process
GO:0050679 IEA:EnsemblPpositive regulation of epithelial cell proliferation
GO:0010718 IDA:BHF-UCLPpositive regulation of epithelial to mesenchymal transition
GO:0031536 IEA:EnsemblPpositive regulation of exit from mitosis
GO:1901203 IC:BHF-UCLPpositive regulation of extracellular matrix assembly
GO:0010763 IDA:BHF-UCLPpositive regulation of fibroblast migration
GO:0010628 IDA:UniProtKBPpositive regulation of gene expression
GO:0035066 IEA:EnsemblPpositive regulation of histone acetylation
GO:0031065 IEA:EnsemblPpositive regulation of histone deacetylation
GO:0032740 IDA:BHF-UCLPpositive regulation of interleukin-17 production
GO:0048298 IDA:MGIPpositive regulation of isotype switching to IgA isotypes
GO:0043406 IDA:BHF-UCLPpositive regulation of MAP kinase activity
GO:1901666 IDA:BHF-UCLPpositive regulation of NAD+ ADP-ribosyltransferase activity
GO:0051092 IEA:EnsemblPpositive regulation of NF-kappaB transcription factor activity
GO:0042482 IEA:EnsemblPpositive regulation of odontogenesis
GO:0010862 IDA:BHF-UCLPpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0033138 IDA:BHF-UCLPpositive regulation of peptidyl-serine phosphorylation
GO:0010800 IDA:BHF-UCLPpositive regulation of peptidyl-threonine phosphorylation
GO:0043552 IDA:BHF-UCLPpositive regulation of phosphatidylinositol 3-kinase activity
GO:0031334 IDA:BHF-UCLPpositive regulation of protein complex assembly
GO:0035307 IDA:BHF-UCLPpositive regulation of protein dephosphorylation
GO:0042307 IDA:BHF-UCLPpositive regulation of protein import into nucleus
GO:0051897 IDA:BHF-UCLPpositive regulation of protein kinase B signaling
GO:0001934 IDA:BHF-UCLPpositive regulation of protein phosphorylation
GO:0050714 IDA:BHF-UCLPpositive regulation of protein secretion
GO:0060391 IDA:BHF-UCLPpositive regulation of SMAD protein import into nucleus
GO:0051152 IEA:EnsemblPpositive regulation of smooth muscle cell differentiation
GO:0032930 IDA:BHF-UCLPpositive regulation of superoxide anion generation
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:2000679 IDA:BHF-UCLPpositive regulation of transcription regulatory region DNA binding
GO:0010575 TAS:BHF-UCLPpositive regulation vascular endothelial growth factor production
GO:0006611 IDA:UniProtKBPprotein export from nucleus
GO:0000060 IDA:UniProtKBPprotein import into nucleus, translocation
GO:0043491 IMP:UniProtKBPprotein kinase B signaling
GO:0006468 ISS:UniProtKBPprotein phosphorylation
GO:0032801 IDA:BHF-UCLPreceptor catabolic process
GO:2000249 IEA:EnsemblPregulation of actin cytoskeleton reorganization
GO:0042981 IBA:GO_CentralPregulation of apoptotic process
GO:0051098 ISS:UniProtKBPregulation of binding
GO:0060312 IC:BHF-UCLPregulation of blood vessel remodeling
GO:0060762 IEA:EnsemblPregulation of branching involved in mammary gland duct morphogenesis
GO:0061035 IEA:EnsemblPregulation of cartilage development
GO:0030334 TAS:BHF-UCLPregulation of cell migration
GO:0051101 ISS:UniProtKBPregulation of DNA binding
GO:2000628 IDA:BHF-UCLPregulation of miRNA metabolic process
GO:0042306 ISS:UniProtKBPregulation of protein import into nucleus
GO:0002028 IEA:EnsemblPregulation of sodium ion transport
GO:0016202 ISS:UniProtKBPregulation of striated muscle tissue development
GO:0017015 IDA:BHF-UCLPregulation of transforming growth factor beta receptor signaling pathway
GO:0045066 IEA:EnsemblPregulatory T cell differentiation
GO:0070723 IDA:BHF-UCLPresponse to cholesterol
GO:0042493 IEA:EnsemblPresponse to drug
GO:0032355 IDA:BHF-UCLPresponse to estradiol
GO:0009749 IEA:EnsemblPresponse to glucose
GO:0001666 IEA:EnsemblPresponse to hypoxia
GO:0034616 IEA:EnsemblPresponse to laminar fluid shear stress
GO:0032570 IDA:BHF-UCLPresponse to progesterone
GO:0009314 IEA:EnsemblPresponse to radiation
GO:0033280 IEA:EnsemblPresponse to vitamin D
GO:0009611 IEP:BHF-UCLPresponse to wounding
GO:0007435 IEP:BHF-UCLPsalivary gland morphogenesis
GO:0007183 IDA:BHF-UCLPSMAD protein complex assembly
GO:0007184 IDA:BHF-UCLPSMAD protein import into nucleus
GO:0060395 IBA:GO_CentralPSMAD protein signal transduction
GO:0043029 IEA:EnsemblPT cell homeostasis
GO:0002513 IEA:EnsemblPtolerance induction to self antigen
GO:0007179 IDA:BHF-UCLPtransforming growth factor beta receptor signaling pathway
GO:0001657 IEA:EnsemblPureteric bud development
GO:0019058 TAS:ReactomePviral life cycle
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111045Developmental Biology
REACT_116125Disease
REACT_120727Downregulation of TGF-beta receptor signaling
REACT_163906ECM proteoglycans
REACT_150366Elastic fibre formation
REACT_118779Extracellular matrix organization
REACT_604Hemostasis
REACT_6323Host Interactions with Influenza Factors
REACT_6167Influenza Infection
REACT_6213Influenza Virus Induced Apoptosis
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_150331Molecules associated with elastic fibres
REACT_163874Non-integrin membrane-ECM interactions
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_163942Syndecan interactions
REACT_120850TGF-beta receptor signaling activates SMADs
REACT_120726TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_27161Transcriptional regulation of white adipocyte differentiation
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