MGP Database

MGP003120

Record overview

MGPD ID	MGP003120
Gene ID	7043
Species	Homo sapiens (Human)
Gene Name	transforming growth factor, beta 3
Gene Symbol	TGFB3
Synonyms	ARVD; RNHF; ARVD1; TGF-beta3;
Alternate names	transforming growth factor beta-3; TGF-beta-3; prepro-transforming growth factor beta-3;
Chromosome	14
Map Location	14q24
Summary	This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]
Orthologs	View orthologs and multiple alignments for TGFB3

Proteins

transforming growth factor beta-3 preproprotein

Refseq ID:	NP_003230
Protein GI:	4507465
UniProt ID:	P10600
mRNA ID:	NM_003239
Length:	412
RefSeq Status:

MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEY
YAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGKNLPTRGTAEWL
SFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR
ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQ
LSNMVVKSCKCS

sig_peptide: 1..23
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2556
peptide sequence: 
MKMHLQRALVVLALLNFATVSLS

mat_peptide: 24..300
product: Latency-associated peptide
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P10600.1)
calculated_mol_wt: 32086
peptide sequence: 
LSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVC
PKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEI
SIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR

mat_peptide: 301..412
product: Transforming growth factor beta-3
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P10600.1)
calculated_mol_wt: 12723
peptide sequence: 
ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQ
LSNMVVKSCKCS