MGP Database

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MGP003120

Ontology/Pathway Information

Entrez Gene ID7043
Gene Nametransforming growth factor, beta 3
Gene Symbol TGFB3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IEA:EnsemblCcell surface
GO:0031012 IDA:BHF-UCLCextracellular matrix
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IBA:GO_CentralCextracellular space
GO:0043025 IEA:EnsemblCneuronal cell body
GO:0005634 IEA:EnsemblCnucleus
GO:0005886 IC:BHF-UCLCplasma membrane
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0030315 IEA:EnsemblCT-tubule
GO:0005125 IBA:GO_CentralFcytokine activity
GO:0042802 IDA:BHF-UCLFidentical protein binding
GO:0050431 IDA:BHF-UCLFtransforming growth factor beta binding
GO:0005114 IDA:BHF-UCLFtype II transforming growth factor beta receptor binding
GO:0034713 IDA:BHF-UCLFtype I transforming growth factor beta receptor binding
GO:0000187 IEA:EnsemblPactivation of MAPK activity
GO:0007568 IEA:EnsemblPaging
GO:0007596 TAS:ReactomePblood coagulation
GO:0045216 IDA:BHF-UCLPcell-cell junction organization
GO:0016049 IEA:InterProPcell growth
GO:0070483 IDA:BHF-UCLPdetection of hypoxia
GO:0048565 IEA:EnsemblPdigestive tract development
GO:0048702 IEA:EnsemblPembryonic neurocranium morphogenesis
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0060325 IMP:BHF-UCLPface morphogenesis
GO:0007565 IEA:EnsemblPfemale pregnancy
GO:0060364 IEA:EnsemblPfrontal suture morphogenesis
GO:0048839 IEA:EnsemblPinner ear development
GO:0001701 ISS:BHF-UCLPin utero embryonic development
GO:0048286 ISS:BHF-UCLPlung alveolus development
GO:0030879 ISS:BHF-UCLPmammary gland development
GO:0008285 ISS:BHF-UCLPnegative regulation of cell proliferation
GO:0008156 IMP:BHF-UCLPnegative regulation of DNA replication
GO:0010936 IDA:DFLATPnegative regulation of macrophage cytokine production
GO:0043524 ISS:BHF-UCLPnegative regulation of neuron apoptotic process
GO:0030512 IEA:EnsemblPnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0042476 NAS:BHF-UCLPodontogenesis
GO:0043932 IEP:BHF-UCLPossification involved in bone remodeling
GO:0060021 ISS:BHF-UCLPpalate development
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0043065 ISS:BHF-UCLPpositive regulation of apoptotic process
GO:0030501 IEP:BHF-UCLPpositive regulation of bone mineralization
GO:0051781 IEA:UniProtKB-KWPpositive regulation of cell division
GO:0032967 IMP:BHF-UCLPpositive regulation of collagen biosynthetic process
GO:0045740 IMP:BHF-UCLPpositive regulation of DNA replication
GO:0010718 IDA:BHF-UCLPpositive regulation of epithelial to mesenchymal transition
GO:0051491 ISS:BHF-UCLPpositive regulation of filopodium assembly
GO:0010862 ISS:BHF-UCLPpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0050714 IDA:BHF-UCLPpositive regulation of protein secretion
GO:0060391 ISS:BHF-UCLPpositive regulation of SMAD protein import into nucleus
GO:0045893 IDA:BHF-UCLPpositive regulation of transcription, DNA-templated
GO:0045944 ISS:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0042981 IBA:GO_CentralPregulation of apoptotic process
GO:0042127 IBA:GO_CentralPregulation of cell proliferation
GO:0043408 IBA:GO_CentralPregulation of MAPK cascade
GO:0043627 IEA:EnsemblPresponse to estrogen
GO:0001666 IDA:BHF-UCLPresponse to hypoxia
GO:0034616 IEA:EnsemblPresponse to laminar fluid shear stress
GO:0032570 IDA:BHF-UCLPresponse to progesterone
GO:0007435 IEP:BHF-UCLPsalivary gland morphogenesis
GO:0007184 IEA:EnsemblPSMAD protein import into nucleus
GO:0060395 IBA:GO_CentralPSMAD protein signal transduction
GO:0007179 IDA:BHF-UCLPtransforming growth factor beta receptor signaling pathway
GO:0042704 TAS:BHF-UCLPuterine wall breakdown
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_163906ECM proteoglycans
REACT_150366Elastic fibre formation
REACT_118779Extracellular matrix organization
REACT_604Hemostasis
REACT_150331Molecules associated with elastic fibres
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
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