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MGP003125

Record overview

MGPD IDMGP003125
Gene ID7050
SpeciesHomo sapiens (Human)
Gene NameTGFB-induced factor homeobox 1
Gene Symbol TGIF1
SynonymsHPE4; TGIF;
Alternate nameshomeobox protein TGIF1; 5'-TG-3'-interacting factor 1; TALE homeobox TG-interacting factor; transforming growth factor-beta-induced factor;
Chromosome18
Map Location18p11.3
SummaryThe protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
OrthologsView orthologs and multiple alignments for TGIF1

Proteins

homeobox protein TGIF1 isoform a
Refseq ID:NP_733796
Protein GI:28178843
UniProt ID:Q15583
mRNA ID:NM_170695
Length:401
RefSeq Status:
MVLAQSRVSAGVGSPHCSGSGGGGSDSFPWPASHPGNPQCSFSTAFLASPRLSRGTLAYLPPAPWSSLATPSALLGSSCAPPPPPARCPQPRALSPELGT
KAGPRRPHRWELPRSPSQGAQGPAPRRRLLETMKGIVAASGSETEDEDSMDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPSEQEKALL
SQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISETSSVESVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPS
VICHTTVTALKDVPFSLCQSVGVGQNTDIQQIAAKNFTDTSLMYPEDTCKSGPSTNTQSGLFNTPPPTPPDLNQDFSGFQLLVDVALKRAAEMELQAKLT
A
 
homeobox protein TGIF1 isoform b
Refseq ID:NP_775299
Protein GI:28178845
UniProt ID:Q15583
mRNA ID:NM_173207
Length:286
RefSeq Status:
MTCSGKSCALARSSLTSSQGIVAASGSETEDEDSMDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWF
INARRRLLPDMLRKDGKDPNQFTISRRGAKISETSSVESVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTALKDVPF
SLCQSVGVGQNTDIQQIAAKNFTDTSLMYPEDTCKSGPSTNTQSGLFNTPPPTPPDLNQDFSGFQLLVDVALKRAAEMELQAKLTA
 
homeobox protein TGIF1 isoform c
Refseq ID:NP_775300
Protein GI:28178849
UniProt ID:Q15583
mRNA ID:NM_173208
Length:272
RefSeq Status:
MKGKKGIVAASGSETEDEDSMDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRK
DGKDPNQFTISRRGAKISETSSVESVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTALKDVPFSLCQSVGVGQNTDI
QQIAAKNFTDTSLMYPEDTCKSGPSTNTQSGLFNTPPPTPPDLNQDFSGFQLLVDVALKRAAEMELQAKLTA
 
homeobox protein TGIF1 isoform c
Refseq ID:NP_003235
Protein GI:4507473
UniProt ID:Q15583
mRNA ID:NM_003244
Length:272
RefSeq Status:
Protein sequence is identical to GI:28178849 (mRNA isoform)
 
homeobox protein TGIF1 isoform c
Refseq ID:NP_001265613
Protein GI:522838242
UniProt ID:Q15583
mRNA ID:NM_001278684
Length:272
RefSeq Status:
Protein sequence is identical to GI:28178849 (mRNA isoform)
 
homeobox protein TGIF1 isoform d
Refseq ID:NP_775301
Protein GI:28178851
UniProt ID:Q15583
mRNA ID:NM_173209
Length:252
RefSeq Status:
MDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISET
SSVESVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTALKDVPFSLCQSVGVGQNTDIQQIAAKNFTDTSLMYPEDTC
KSGPSTNTQSGLFNTPPPTPPDLNQDFSGFQLLVDVALKRAAEMELQAKLTA
 
homeobox protein TGIF1 isoform d
Refseq ID:NP_775302
Protein GI:28178853
UniProt ID:Q15583
mRNA ID:NM_173210
Length:252
RefSeq Status:
Protein sequence is identical to GI:28178851 (mRNA isoform)
 
homeobox protein TGIF1 isoform d
Refseq ID:NP_775303
Protein GI:28178855
UniProt ID:Q15583
mRNA ID:NM_173211
Length:252
RefSeq Status:
Protein sequence is identical to GI:28178851 (mRNA isoform)
 
homeobox protein TGIF1 isoform d
Refseq ID:NP_001265615
Protein GI:522838246
UniProt ID:Q15583
mRNA ID:NM_001278686
Length:252
RefSeq Status:
Protein sequence is identical to GI:28178851 (mRNA isoform)
 
homeobox protein TGIF1 isoform d
Refseq ID:NP_777480
Protein GI:28178857
UniProt ID:Q15583
mRNA ID:NM_174886
Length:252
RefSeq Status:
Protein sequence is identical to GI:28178851 (mRNA isoform)
 
homeobox protein TGIF1 isoform e
Refseq ID:NP_001265611
Protein GI:522838237
UniProt ID:Q15583
mRNA ID:NM_001278682
Length:275
RefSeq Status:
MAAAHSGRSIVAASGSETEDEDSMDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRRLLPDM
LRKDGKDPNQFTISRRGAKISETSSVESVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTALKDVPFSLCQSVGVGQN
TDIQQIAAKNFTDTSLMYPEDTCKSGPSTNTQSGLFNTPPPTPPDLNQDFSGFQLLVDVALKRAAEMELQAKLTA
 
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