MGP Database

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MGP003125

Ontology/Pathway Information

Entrez Gene ID7050
Gene NameTGFB-induced factor homeobox 1
Gene Symbol TGIF1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005654 IDA:HPACnucleoplasm
GO:0003682 IEA:EnsemblFchromatin binding
GO:0000978 IDA:NTNU_SBFRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 IDA:NTNU_SBFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700 TAS:ProtIncFsequence-specific DNA binding transcription factor activity
GO:0003714 TAS:ProtIncFtranscription corepressor activity
GO:0007368 IEA:EnsemblPdetermination of left/right symmetry
GO:0009953 IEA:EnsemblPdorsal/ventral pattern formation
GO:0010467 TAS:ReactomePgene expression
GO:0007275 TAS:ProtIncPmulticellular organismal development
GO:0008285 IEA:EnsemblPnegative regulation of cell proliferation
GO:0048387 IEA:EnsemblPnegative regulation of retinoic acid receptor signaling pathway
GO:0000122 IDA:NTNU_SBPnegative regulation of transcription from RNA polymerase II promoter
GO:0001843 IEA:EnsemblPneural tube closure
GO:0038092 IEA:EnsemblPnodal signaling pathway
GO:0048146 IEA:EnsemblPpositive regulation of fibroblast proliferation
GO:0045666 IEA:EnsemblPpositive regulation of neuron differentiation
GO:0010470 IEA:EnsemblPregulation of gastrulation
GO:0042493 IEA:EnsemblPresponse to drug
GO:0060041 IEA:EnsemblPretina development in camera-type eye
GO:0006351 TAS:ReactomePtranscription, DNA-templated
GO:0006367 TAS:ReactomePtranscription initiation from RNA polymerase II promoter
GO:0007179 TAS:ReactomePtransforming growth factor beta receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_116125Disease
REACT_121111Downregulation of SMAD2/3:SMAD4 transcriptional activity
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_111102Signal Transduction
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_120734SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
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