MGP Database

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MGP003128

Ontology/Pathway Information

Entrez Gene ID7057
Gene Namethrombospondin 1
Gene Symbol THBS1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0009986 IDA:BHF-UCLCcell surface
GO:0005783 ISS:UniProtKBCendoplasmic reticulum
GO:0009897 IDA:BHF-UCLCexternal side of plasma membrane
GO:0031012 IDA:UniProtKBCextracellular matrix
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005577 IDA:BHF-UCLCfibrinogen complex
GO:0031091 IDA:BHF-UCLCplatelet alpha granule
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0016529 ISS:UniProtKBCsarcoplasmic reticulum
GO:0030141 IDA:BHF-UCLCsecretory granule
GO:0005509 NAS:BHF-UCLFcalcium ion binding
GO:0070052 IDA:BHF-UCLFcollagen V binding
GO:0070051 IDA:BHF-UCLFfibrinogen binding
GO:0017134 IDA:BHF-UCLFfibroblast growth factor binding
GO:0001968 IDA:BHF-UCLFfibronectin binding
GO:0001948 NAS:BHF-UCLFglycoprotein binding
GO:0008201 IDA:BHF-UCLFheparin binding
GO:0042802 NAS:BHF-UCLFidentical protein binding
GO:0005178 IMP:BHF-UCLFintegrin binding
GO:0043236 IDA:BHF-UCLFlaminin binding
GO:0030169 IDA:BHF-UCLFlow-density lipoprotein particle binding
GO:0001786 IDA:UniProtKBFphosphatidylserine binding
GO:0043394 TAS:BHF-UCLFproteoglycan binding
GO:0050431 ISS:BHF-UCLFtransforming growth factor beta binding
GO:0000187 IMP:BHF-UCLPactivation of MAPK activity
GO:0048266 ISS:UniProtKBPbehavioral response to pain
GO:0007596 TAS:ReactomePblood coagulation
GO:0007155 NAS:BHF-UCLPcell adhesion
GO:0007050 IDA:BHF-UCLPcell cycle arrest
GO:0016477 IDA:BHF-UCLPcell migration
GO:0071363 IEA:EnsemblPcellular response to growth factor stimulus
GO:0034605 NAS:BHF-UCLPcellular response to heat
GO:0071356 IEA:EnsemblPcellular response to tumor necrosis factor
GO:0002544 IEP:BHF-UCLPchronic inflammatory response
GO:0003197 IEA:EnsemblPendocardial cushion development
GO:0043652 IDA:BHF-UCLPengulfment of apoptotic cell
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0003417 IEA:EnsemblPgrowth plate cartilage development
GO:0006955 IEP:BHF-UCLPimmune response
GO:0016525 IDA:UniProtKBPnegative regulation of angiogenesis
GO:0002581 IDA:BHF-UCLPnegative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0043066 IDA:UniProtKBPnegative regulation of apoptotic process
GO:0043537 IDA:BHF-UCLPnegative regulation of blood vessel endothelial cell migration
GO:0001953 IDA:BHF-UCLPnegative regulation of cell-matrix adhesion
GO:0010754 IDA:BHF-UCLPnegative regulation of cGMP-mediated signaling
GO:0043154 IDA:UniProtKBPnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0002605 IDA:BHF-UCLPnegative regulation of dendritic cell antigen processing and presentation
GO:2001027 IDA:MGIPnegative regulation of endothelial cell chemotaxis
GO:0010596 IDA:BHF-UCLPnegative regulation of endothelial cell migration
GO:0001937 IDA:BHF-UCLPnegative regulation of endothelial cell proliferation
GO:2001237 TAS:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway
GO:0051918 IDA:BHF-UCLPnegative regulation of fibrinolysis
GO:0040037 IDA:BHF-UCLPnegative regulation of fibroblast growth factor receptor signaling pathway
GO:0051895 TAS:BHF-UCLPnegative regulation of focal adhesion assembly
GO:0032695 IDA:BHF-UCLPnegative regulation of interleukin-12 production
GO:0010751 IDA:BHF-UCLPnegative regulation of nitric oxide mediated signal transduction
GO:0010748 IDA:BHF-UCLPnegative regulation of plasma membrane long-chain fatty acid transport
GO:0010757 IDA:BHF-UCLPnegative regulation of plasminogen activation
GO:0003151 IEA:EnsemblPoutflow tract morphogenesis
GO:0018149 IDA:BHF-UCLPpeptide cross-linking
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0045766 IMP:BHF-UCLPpositive regulation of angiogenesis
GO:0030194 IDA:BHF-UCLPpositive regulation of blood coagulation
GO:0043536 IDA:BHF-UCLPpositive regulation of blood vessel endothelial cell migration
GO:0030335 IDA:BHF-UCLPpositive regulation of cell migration
GO:0010811 IEA:EnsemblPpositive regulation of cell-substrate adhesion
GO:0050921 IDA:BHF-UCLPpositive regulation of chemotaxis
GO:2000353 IDA:UniProtKBPpositive regulation of endothelial cell apoptotic process
GO:0010595 IDA:BHF-UCLPpositive regulation of endothelial cell migration
GO:1902043 IDA:BHF-UCLPpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0010763 IDA:BHF-UCLPpositive regulation of fibroblast migration
GO:0043032 IDA:BHF-UCLPpositive regulation of macrophage activation
GO:0010759 ISS:BHF-UCLPpositive regulation of macrophage chemotaxis
GO:0042327 IMP:BHF-UCLPpositive regulation of phosphorylation
GO:0051897 IDA:UniProtKBPpositive regulation of protein kinase B signaling
GO:2000379 IDA:BHF-UCLPpositive regulation of reactive oxygen species metabolic process
GO:0032914 ISS:BHF-UCLPpositive regulation of transforming growth factor beta1 production
GO:0030511 IDA:BHF-UCLPpositive regulation of transforming growth factor beta receptor signaling pathway
GO:0045727 IDA:BHF-UCLPpositive regulation of translation
GO:0042535 IDA:UniProtKBPpositive regulation of tumor necrosis factor biosynthetic process
GO:0030823 IDA:MGIPregulation of cGMP metabolic process
GO:0051592 IDA:BHF-UCLPresponse to calcium ion
GO:0042493 IEP:UniProtKBPresponse to drug
GO:0034976 ISS:UniProtKBPresponse to endoplasmic reticulum stress
GO:0009749 IDA:BHF-UCLPresponse to glucose
GO:0001666 NAS:BHF-UCLPresponse to hypoxia
GO:0032026 IDA:BHF-UCLPresponse to magnesium ion
GO:0009612 IEA:EnsemblPresponse to mechanical stimulus
GO:0032570 TAS:BHF-UCLPresponse to progesterone
GO:0033574 IEA:EnsemblPresponse to testosterone
GO:0006986 IEA:UniProtKB-KWPresponse to unfolded protein
GO:0002040 IMP:BHF-UCLPsprouting angiogenesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_118779Extracellular matrix organization
REACT_604Hemostasis
REACT_13552Integrin cell surface interactions
REACT_17015Metabolism of proteins
REACT_163874Non-integrin membrane-ECM interactions
REACT_264269O-glycosylation of TSR domain-containing proteins
REACT_263902O-linked glycosylation
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_22161Post-translational protein modification
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_16888Signaling by PDGF
REACT_111102Signal Transduction
REACT_163942Syndecan interactions
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