MGP Database

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MGP003128

UniProt Annotations

Entry Information
Gene Namethrombospondin 1
Protein EntryTSP1_HUMAN
UniProt IDP07996
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P07996-1; Sequence=Displayed; Name=2; IsoId=P07996-2; Sequence=VSP_055757; Note=No experimental confirmation available.;
FunctionAdhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). {ECO:0000250}.
InteractionQ15113:PCOLCE; NbExp=3; IntAct=EBI-2530274, EBI-8869614; P01137:TGFB1; NbExp=2; IntAct=EBI-2530274, EBI-779636;
Sequence CautionSequence=BAD93149.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the thrombospondin family. {ECO:0000305}.
SimilarityContains 1 laminin G-like domain. {ECO:0000305}.
SimilarityContains 1 TSP C-terminal (TSPC) domain. {ECO:0000255|PROSITE-ProRule:PRU00635}.
SimilarityContains 1 VWFC domain. {ECO:0000255|PROSITE- ProRule:PRU00220}.
SimilarityContains 2 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}.
SimilarityContains 3 TSP type-1 domains. {ECO:0000255|PROSITE- ProRule:PRU00210}.
SimilarityContains 8 TSP type-3 repeats. {ECO:0000255|PROSITE- ProRule:PRU00634}.
Subcellular LocationEndoplasmic reticulum {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250}.
SubunitHomotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS1 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta- 1, alpha-V/beta-3 and alpha-IIb/beta-3. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts with ATF6 (via lumenal domain) (By similarity). {ECO:0000250}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/THBS1ID42548ch15q15.html";
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