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MGP003135

UniProt Annotations

Entry Information

Gene Name	T-cell lymphoma invasion and metastasis 1
Protein Entry	TIAM1_HUMAN
UniProt ID	Q13009
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13009-1; Sequence=Displayed; Name=2; IsoId=Q13009-2; Sequence=VSP_055865, VSP_055866; Note=No experimental confirmation available.;
Domain	The first PH domain mediates interaction with membranes enriched in phosphoinositides. {ECO:0000250}.
Function	Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration. {ECO:0000269\|PubMed:20361982}.
Similarity	Belongs to the TIAM family. {ECO:0000305}.
Similarity	Contains 1 DH (DBL-homology) domain. {ECO:0000255\|PROSITE-ProRule:PRU00062}.
Similarity	Contains 1 PDZ (DHR) domain. {ECO:0000255\|PROSITE- ProRule:PRU00143}.
Similarity	Contains 1 RBD (Ras-binding) domain. {ECO:0000255\|PROSITE-ProRule:PRU00262}.
Similarity	Contains 2 PH domains. {ECO:0000255\|PROSITE- ProRule:PRU00145}.
Subcellular Location	Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.
Subunit	Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with NTRK2; mediates the activation of RAC1 by BDNF. Interacts with MAPK8IP2 and CD44 (By similarity). Interacts with BAIAP2. Interacts with EPHA8; regulates clathrin-mediated endocytosis of EPHA8. Interacts with PARD3. Interacts (via PDZ domain) with CNTNAP4, SDC1 and SDC3 (via C-terminus). {ECO:0000250, ECO:0000269\|PubMed:15899863, ECO:0000269\|PubMed:20332120, ECO:0000269\|PubMed:20361982, ECO:0000269\|PubMed:20496116, ECO:0000269\|PubMed:23395182, ECO:0000269\|PubMed:23832200, ECO:0000269\|PubMed:7753201}.
Tissue Specificity	Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/TIAM1ID42557ch21q22.html";