MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003136

Record overview

MGPD IDMGP003136
Gene ID7076
SpeciesHomo sapiens (Human)
Gene NameTIMP metallopeptidase inhibitor 1
Gene Symbol TIMP1
SynonymsEPA; EPO; HCI; CLGI; TIMP;
Alternate namesmetalloproteinase inhibitor 1; TIMP-1; collagenase inhibitor; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinases 1;
ChromosomeX
Map LocationXp11.3-p11.23
SummaryThis gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for TIMP1

Proteins

metalloproteinase inhibitor 1 precursor
Refseq ID:NP_003245
Protein GI:4507509
UniProt ID:P01033
mRNA ID:NM_003254
Length:207
RefSeq Status:
MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSH
NRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQ
SLRSQIA
 
sig_peptide: 1..23
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2480
peptide sequence: 
MAPFEPLASGILLLLWLIAPSRA

mat_peptide: 24..207
product: metalloproteinase inhibitor 1
calculated_mol_wt: 20709
peptide sequence: 
CTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCS
FVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA
 
  logo