MGP Database

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MGP003136

Ontology/Pathway Information

Entrez Gene ID7076
Gene NameTIMP metallopeptidase inhibitor 1
Gene Symbol TIMP1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005604 IEA:EnsemblCbasement membrane
GO:0005576 NAS:UniProtKBCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0005125 IDA:UniProtKBFcytokine activity
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0008191 IDA:UniProtKBFmetalloendopeptidase inhibitor activity
GO:0007568 IEA:EnsemblPaging
GO:0007596 TAS:ReactomePblood coagulation
GO:0022617 TAS:ReactomePextracellular matrix disassembly
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0043066 IEA:EnsemblPnegative regulation of apoptotic process
GO:0010951 IDA:UniProtKBPnegative regulation of endopeptidase activity
GO:0051045 IDA:UniProtKBPnegative regulation of membrane protein ectodomain proteolysis
GO:0048553 IDA:UniProtKBPnegative regulation of metalloenzyme activity
GO:1901164 IMP:BHF-UCLPnegative regulation of trophoblast cell migration
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0008284 IDA:UniProtKBPpositive regulation of cell proliferation
GO:2001044 IMP:UniProtKBPregulation of integrin-mediated signaling pathway
GO:0034097 IEA:EnsemblPresponse to cytokine
GO:0043434 IEA:EnsemblPresponse to peptide hormone
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_118682Activation of Matrix Metalloproteinases
REACT_118572Degradation of the extracellular matrix
REACT_118779Extracellular matrix organization
REACT_604Hemostasis
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
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