MGP Database

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MGP003139

UniProt Annotations

Entry Information
Gene Namethymidine kinase 1, soluble
Protein EntryKITH_HUMAN
UniProt IDP04183
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + thymidine = ADP + thymidine 5'- phosphate.
InteractionSelf; NbExp=2; IntAct=EBI-712550, EBI-712550;
MiscellaneousTwo forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.
PtmPhosphorylated on Ser-13 in mitosis. {ECO:0000269|PubMed:16964243, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:9575153}.
SimilarityBelongs to the thymidine kinase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomotetramer. {ECO:0000269|PubMed:15611477, ECO:0000269|PubMed:15733844, ECO:0000269|PubMed:17407781}.
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