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MGP003148

UniProt Annotations

Entry Information
Gene Nametalin 1
Protein EntryTLN1_HUMAN
UniProt IDQ9Y490
SpeciesHuman
Comments
Comment typeDescription
FunctionProbably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity). {ECO:0000250}.
InteractionP00533:EGFR; NbExp=2; IntAct=EBI-2462036, EBI-297353; P04626:ERBB2; NbExp=3; IntAct=EBI-2462036, EBI-641062; P05556:ITGB1; NbExp=2; IntAct=EBI-2462036, EBI-703066; P05106:ITGB3; NbExp=4; IntAct=EBI-2462036, EBI-702847;
Sequence CautionSequence=BAA82979.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityContains 1 FERM domain. {ECO:0000255|PROSITE- ProRule:PRU00084}.
SimilarityContains 1 I/LWEQ domain. {ECO:0000255|PROSITE- ProRule:PRU00292}.
Subcellular LocationCell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell surface {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity). {ECO:0000250}.
SubunitBinds with high affinity to VCL and with low affinity to integrins. Interacts with APBB1IP; this inhibits VCL binding. Interacts with PTK2/FAK1 (By similarity). Interacts with PIP5K1C and NRAP. Interacts with LAYN. Interacts with SYNM. Interacts with ITGB1; the interaction is prevented by competitive binding of ITGB1BP1. {ECO:0000250, ECO:0000269|PubMed:10320340, ECO:0000269|PubMed:12422220, ECO:0000269|PubMed:12473654, ECO:0000269|PubMed:15070891, ECO:0000269|PubMed:18342854, ECO:0000269|PubMed:21768292}.
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