MGP Database

MGP003149

Ontology/Pathway Information

Entrez Gene ID	7097
Gene Name	toll-like receptor 2
Gene Symbol	TLR2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0044297	IEA:Ensembl	C	cell body
GO:0042995	IEA:Ensembl	C	cell projection
GO:0009986	IDA:UniProtKB	C	cell surface
GO:0005737	IDA:BHF-UCL	C	cytoplasm
GO:0009897	IEA:Ensembl	C	external side of plasma membrane
GO:0005887	TAS:ProtInc	C	integral component of plasma membrane
GO:0005886	IDA:BHF-UCL	C	plasma membrane
GO:0035354	IDA:MGI	C	Toll-like receptor 1-Toll-like receptor 2 protein complex
GO:0035355	IEA:Ensembl	C	Toll-like receptor 2-Toll-like receptor 6 protein complex
GO:0042498	IEA:Ensembl	F	diacyl lipopeptide binding
GO:0001875	TAS:UniProtKB	F	lipopolysaccharide receptor activity
GO:0070891	IEA:Ensembl	F	lipoteichoic acid binding
GO:0042834	IDA:UniProtKB	F	peptidoglycan binding
GO:0046982	IDA:MGI	F	protein heterodimerization activity
GO:0004872	IDA:UniProtKB	F	receptor activity
GO:0008329	IDA:UniProtKB	F	signaling pattern recognition receptor activity
GO:0004888	IEA:InterPro	F	transmembrane signaling receptor activity
GO:0042497	IDA:MGI	F	triacyl lipopeptide binding
GO:0006915	TAS:ProtInc	P	apoptotic process
GO:0002752	IEA:Ensembl	P	cell surface pattern recognition receptor signaling pathway
GO:0071221	TAS:BHF-UCL	P	cellular response to bacterial lipopeptide
GO:0071726	IDA:MGI	P	cellular response to diacyl bacterial lipopeptide
GO:0071223	IDA:MGI	P	cellular response to lipoteichoic acid
GO:0071224	IEA:Ensembl	P	cellular response to peptidoglycan
GO:0071727	IDA:MGI	P	cellular response to triacyl bacterial lipopeptide
GO:0032289	IEA:Ensembl	P	central nervous system myelin formation
GO:0042892	IEA:Ensembl	P	chloramphenicol transport
GO:0050830	IDA:UniProtKB	P	defense response to Gram-positive bacterium
GO:0042496	IDA:MGI	P	detection of diacyl bacterial lipopeptide
GO:0042495	IDA:MGI	P	detection of triacyl bacterial lipopeptide
GO:0007252	IDA:BHF-UCL	P	I-kappaB phosphorylation
GO:0006955	TAS:ProtInc	P	immune response
GO:0052063	IEA:Ensembl	P	induction by symbiont of defense-related host nitric oxide production
GO:0006954	IEA:UniProtKB-KW	P	inflammatory response
GO:0045087	TAS:BHF-UCL	P	innate immune response
GO:0006691	IEA:Ensembl	P	leukotriene metabolic process
GO:0031663	TAS:GOC	P	lipopolysaccharide-mediated signaling pathway
GO:0001774	IEA:Ensembl	P	microglial cell activation
GO:0002755	TAS:Reactome	P	MyD88-dependent toll-like receptor signaling pathway
GO:0008285	IEA:Ensembl	P	negative regulation of cell proliferation
GO:0044130	IEA:Ensembl	P	negative regulation of growth of symbiont in host
GO:0032695	IEA:Ensembl	P	negative regulation of interleukin-12 production
GO:0032700	IEA:Ensembl	P	negative regulation of interleukin-17 production
GO:0046209	IEA:Ensembl	P	nitric oxide metabolic process
GO:0032722	IDA:BHF-UCL	P	positive regulation of chemokine production
GO:0050715	IEA:Ensembl	P	positive regulation of cytokine secretion
GO:0050729	IC:BHF-UCL	P	positive regulation of inflammatory response
GO:0032728	ISS:BHF-UCL	P	positive regulation of interferon-beta production
GO:0032733	IEA:Ensembl	P	positive regulation of interleukin-10 production
GO:0032735	ISS:BHF-UCL	P	positive regulation of interleukin-12 production
GO:0032741	ISS:BHF-UCL	P	positive regulation of interleukin-18 production
GO:0032755	IDA:BHF-UCL	P	positive regulation of interleukin-6 production
GO:0032757	IDA:BHF-UCL	P	positive regulation of interleukin-8 production
GO:0002687	IEA:Ensembl	P	positive regulation of leukocyte migration
GO:0060907	IEA:Ensembl	P	positive regulation of macrophage cytokine production
GO:0042346	IDA:BHF-UCL	P	positive regulation of NF-kappaB import into nucleus
GO:0051092	IDA:UniProtKB	P	positive regulation of NF-kappaB transcription factor activity
GO:0045429	IEA:Ensembl	P	positive regulation of nitric oxide biosynthetic process
GO:0051770	ISS:BHF-UCL	P	positive regulation of nitric-oxide synthase biosynthetic process
GO:0048714	IEA:Ensembl	P	positive regulation of oligodendrocyte differentiation
GO:0034123	IDA:BHF-UCL	P	positive regulation of toll-like receptor signaling pathway
GO:0045944	ISS:BHF-UCL	P	positive regulation of transcription from RNA polymerase II promoter
GO:0042535	IEA:Ensembl	P	positive regulation of tumor necrosis factor biosynthetic process
GO:0032760	ISS:BHF-UCL	P	positive regulation of tumor necrosis factor production
GO:0030177	IMP:BHF-UCL	P	positive regulation of Wnt signaling pathway
GO:0070542	IEA:Ensembl	P	response to fatty acid
GO:0001666	IEA:Ensembl	P	response to hypoxia
GO:0032868	IEA:Ensembl	P	response to insulin
GO:0002238	IEA:Ensembl	P	response to molecule of fungal origin
GO:0032570	IEA:Ensembl	P	response to progesterone
GO:0009636	IEA:Ensembl	P	response to toxic substance
GO:0007165	TAS:UniProtKB	P	signal transduction
GO:0034134	TAS:Reactome	P	toll-like receptor 2 signaling pathway
GO:0034142	TAS:Reactome	P	toll-like receptor 4 signaling pathway
GO:0002224	TAS:Reactome	P	toll-like receptor signaling pathway
GO:0038123	TAS:Reactome	P	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	TAS:Reactome	P	toll-like receptor TLR6:TLR2 signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_6890	Activated TLR4 signalling
REACT_115897	Beta defensins
REACT_115846	Defensins
REACT_6900	Immune System
REACT_6802	Innate Immune System
REACT_6788	MyD88:Mal cascade initiated on plasma membrane
REACT_7980	Toll Like Receptor 2 (TLR2) Cascade
REACT_6894	Toll Like Receptor 4 (TLR4) Cascade
REACT_6966	Toll-Like Receptors Cascades
REACT_8005	Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006	Toll Like Receptor TLR6:TLR2 Cascade