MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003149

UniProt Annotations

Entry Information
Gene Nametoll-like receptor 2
Protein EntryTLR2_HUMAN
UniProt IDO60603
SpeciesHuman
Comments
Comment typeDescription
DomainEster-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12. {ECO:0000250}.
DomainThe ATG16L1-binding motif mediates interaction with ATG16L1. {ECO:0000269|PubMed:23376921}.
FunctionCooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
InteractionP00533:EGFR; NbExp=2; IntAct=EBI-973722, EBI-297353; C3PTT6:PAUF; NbExp=3; IntAct=EBI-973722, EBI-3505892;
PolymorphismGenetic variations in TLR2 are associated with susceptibility to leprosy [MIM:246300]. Leprosy is a chronic disease associated with depressed cellular (but not humoral) immunity, the bacterium requires a lower temperature than 37 degrees Celsius and thrives particularly in peripheral Schwann cells and macrophages. The Trp-677 polymorphism in the intracellular domain of TLR2 has a role in susceptibility to lepromatous leprosy. Wild-type TLR2 mediates CD14-enhanced Mycobacterium leprae-dependent activation of NFKB1, but TLR2 containing the Trp-677 polymorphism did not. The impaired function of the Trp-677 polymorphism provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy.
PtmGlycosylation of Asn-442 is critical for secretion of the N- terminal ectodomain of TLR2. {ECO:0000269|PubMed:15173186, ECO:0000269|PubMed:17889651}.
SimilarityBelongs to the Toll-like receptor family. {ECO:0000305}.
SimilarityContains 19 LRR (leucine-rich) repeats. {ECO:0000305}.
SimilarityContains 1 LRRCT domain. {ECO:0000305}.
SimilarityContains 1 TIR domain. {ECO:0000255|PROSITE- ProRule:PRU00204}.
Subcellular LocationMembrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
SubunitInteracts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1 or TLR6. Interacts with CNPY3 (By similarity). Interacts with ATG16L1. {ECO:0000250, ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:17889651, ECO:0000269|PubMed:23376921}.
Tissue SpecificityHighly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
  logo